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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
A comparison of sucralfate dosage schedule in duodenal ulcer healing: Two grams twice a day versus one gram four times a day
Journal of Clinical Gastroenterology, Volume 8, No. 4, Year 1986
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Description
The conventional dosage schedule for sucralfate is 1 g 4 i.d., but a dose of 2 g 2 i.d. may be equally effective in duodenal ulcer healing. We compared the efficacy of these two regimens in duodenal ulcer healing. Seventy-seven patients with endoscopically proven duodenal ulceration were entered into a double-blind, controlled study and randomized to treatment with sucralfate 2 g 2 i.d. (on waking and at bedtime) or 1 g 4 i.d. (1/2 h before meals and at bedtime). The patients were endoscoped before entry into the study, after 4 weeks, and after 8 weeks if unhealed at 4 weeks. Of the patients considered suitable for analysis at 4 weeks, 79% (26/33) of those taking 2 g 2 i.d. had healed ulcers in comparison to 72% (23/32) of those taking 1 g 4 i.d. After 8 weeks, cumulative healing rates were 85% (28/33) and 80% (24/30), respectively. The results suggest that the more convenient dosage schedule of 2 g 2 i.d. is as effective as the 1 g 4 i.d. regimen in the short-term treatment of duodenal ulcer. © 1986 Raven Press, New York.
Authors & Co-Authors
Marks, Israel N.Solly
South Africa, Observatory
Groote Schuur Hospital
Wright, John P.
South Africa, Observatory
Groote Schuur Hospital
Gilinsky, Norman H.
South Africa, Observatory
Groote Schuur Hospital
Girdwood, Andrew H.
South Africa, Observatory
Groote Schuur Hospital
Tobias, Raymond
South Africa, Observatory
Groote Schuur Hospital
Boyd, E.
South Africa, Observatory
Groote Schuur Hospital
Kalvaria, I.
South Africa, Observatory
Groote Schuur Hospital
O’Keefe, S. J.
South Africa, Observatory
Groote Schuur Hospital
Newton, Keith A.
South Africa, Observatory
Groote Schuur Hospital
Lücke, Wendy
South Africa, Observatory
Groote Schuur Hospital
Statistics
Citations: 21
Authors: 10
Affiliations: 1
Identifiers
Doi:
10.1097/00004836-198608000-00007
e-ISSN:
15392031
Research Areas
Disability