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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Risk of trachomatous scarring and trichiasis in Gambians varies with SNP haplotypes at the interferon-gamma and interleukin-10 loci
Genes and Immunity, Volume 6, No. 4, Year 2005
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Description
Experimental evidence implicates interferon gamma (IFNγ) in protection from and resolution of chlamydial infection. Conversely, interleukin 10 (IL10) is associated with susceptibility and persistence of infection and pathology. We studied genetic variation within the IL10 and IFNγ loci in relation to the risk of developing severe complications of human ocular Chlamydia trachomatis infection. A total of 651 Gambian subjects with scarring trachoma, of whom 307 also had potentially blinding trichiasis and pair-matched controls with normal eyelids, were screened for associations between single-nucleotide polymorphisms (SNPs), SNP haplotypes and the risk of disease. MassEXTEND (Sequenom) and MALDI-TOF mass spectrometry were used for detection and analysis of SNPs and the programs PHASE and SNPHAP used to infer haplotypes from population genetic data. Multivariate conditional logistic regression analysis identified IL10 and IFNγ SNP haplotypes associated with increased risk of both trachomatous scarring and trichiasis. SNPs in putative IFNγ and IL10 regulatory regions lay within the disease-associated haplotypes. The IFNγ + 874A allele, previously linked to lower IFNγ production, lies in the IFNγ risk haplotype and was more common among cases than controls, but not significantly so. The promoter IL10-1082G allele, previously associated with high IL10 expression, is in both susceptibility and resistance haplotypes. © 2005 Nature Publishing Group. All rights reserved.
Authors & Co-Authors
Natividad, Angels
Unknown Affiliation
Wilson, Jonathan N.
Unknown Affiliation
Koch, Oliver
Unknown Affiliation
Holland, Martin J.
Unknown Affiliation
Rockett, Kirk A.
Unknown Affiliation
Faal, Nkoyo
Unknown Affiliation
Jallow, Ousman
Unknown Affiliation
Joof, O.
Unknown Affiliation
Burton, Matthew J.
Unknown Affiliation
Alexander, Neal Douglas Edward
Unknown Affiliation
Kwiatkowski, Dominic P.
Unknown Affiliation
Mabey, David C.W.
Unknown Affiliation
Bailey, Robin L.
Unknown Affiliation
Statistics
Citations: 70
Authors: 13
Affiliations: 5
Identifiers
Doi:
10.1038/sj.gene.6364182
ISSN:
14664879
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study
Study Approach
Quantitative