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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Characterization of anti-HIV-1 neutralizing and binding antibodies in chronic HIV-1 subtype C infection
Virology, Volume 433, No. 2, Year 2012
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Description
Neutralizing (nAbs) and high affinity binding antibodies may be critical for an efficacious HIV-1 vaccine. We characterized virus-specific nAbs and binding antibody responses over 21 months in eight HIV-1 subtype C chronically infected individuals with heterogeneous rates of disease progression. Autologous nAb titers of study exit plasma against study entry viruses were significantly higher than contemporaneous responses at study entry (p=0.002) and exit (p=0.01). NAb breadth and potencies against subtype C viruses were significantly higher than for subtype A (p=0.03 and p=0.01) or B viruses (p=0.03; p=0.05) respectively. Gp41-IgG binding affinity was higher than gp120-IgG (p=0.0002). IgG-FcγR1 affinity was significantly higher than FcγRIIIa (p<0.005) at study entry and FcγRIIb (p<0.05) or FcγRIIIa (p<0.005) at study exit. Evolving IgG binding suggests alteration of immune function mediated by binding antibodies. Evolution of nAbs was a potential marker of HIV-1 disease progression. © 2012 Elsevier Inc.
Authors & Co-Authors
Archary, Derseree
South Africa, Durban
The Nelson R. Mandela Medical School
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Rong, Rong
China, Suzhou
Xi'an Jiaotong-liverpool University
Gordon, Michelle L.
South Africa, Durban
The Nelson R. Mandela Medical School
Boliar, Saikat
United States, Atlanta
Emory University
Madiga, Maphuti Carol
South Africa, Johannesburg
National Institute for Communicable Diseases
Gray, Elin Solomonovna
Australia, Perth
The University of Western Australia
Dugast, Anne Sophie
United States, Cambridge
Harvard University
Hermanus, Tandile
South Africa, Johannesburg
National Institute for Communicable Diseases
Goulder, Philip Jeremy Renshaw
United Kingdom, Oxford
University of Oxford
Coovadia, Hoosen Mahomed
South Africa, Durban
The Nelson R. Mandela Medical School
Werner, Lise
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Morris, Lynn
South Africa, Johannesburg
National Institute for Communicable Diseases
Alter, Galit
United States, Cambridge
Harvard University
Derdeyn, Cynthia A.
United States, Atlanta
Emory University
Ndung'u, Thumbi P.
South Africa, Durban
The Nelson R. Mandela Medical School
Statistics
Citations: 15
Authors: 15
Affiliations: 8
Identifiers
Doi:
10.1016/j.virol.2012.08.033
ISSN:
00426822
e-ISSN:
10960341
Research Areas
Infectious Diseases