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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Sex as a determinant of relapse incidence and progressive course of multiple sclerosis
Brain, Volume 136, No. 12, Year 2013
Notification
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Description
The aim of this work was to evaluate sex differences in the incidence of multiple sclerosis relapses; assess the relationship between sex and primary progressive disease course; and compare effects of age and disease duration on relapse incidence. Annualized relapse rates were calculated using the MSBase registry. Patients with incomplete data or <1 year of follow-up were excluded. Patients with primary progressive multiple sclerosis were only included in the sex ratio analysis. Relapse incidences over 40 years of multiple sclerosis or 70 years of age were compared between females and males with Andersen-Gill and Tweedie models. Female-to-male ratios stratified by annual relapse count were evaluated across disease duration and patient age and compared between relapse-onset and primary progressive multiple sclerosis. The study cohort consisted of 11 570 eligible patients with relapse-onset and 881 patients with primary progressive multiple sclerosis. Among the relapse-onset patients (82 552 patient-years), 48 362 relapses were recorded. Relapse frequency was 17.7% higher in females compared with males. Within the initial 5 years, the female-to-male ratio increased from 2.3:1 to 3.3:1 in patients with 0 versus ≥4 relapses per year, respectively. The magnitude of this sex effect increased at longer disease duration and older age (P < 10-12). However, the female-to-male ratio in patients with relapse-onset multiple sclerosis and zero relapses in any given year was double that of the patients with primary progressive multiple sclerosis. Patient age was a more important determinant of decline in relapse incidence than disease duration (P < 10-12). Females are predisposed to higher relapse activity than males. However, this difference does not explain the markedly lower female-to-male sex ratio in primary progressive multiple sclerosis. Decline in relapse activity over time is more closely related to patient age than disease duration. © The Author (2013).
Authors & Co-Authors
Kalincik, Tomas
Australia, Melbourne
University of Melbourne
Australia, Melbourne
Royal Melbourne Hospital
Vivek, Vino
Australia, Melbourne
Royal Melbourne Hospital
Jokubaitis, Vilija G.
Australia, Melbourne
University of Melbourne
Lechner-Scott, Jeannette S.
Australia, Newcastle
John Hunter Hospital
Trojano, Maria
Italy, Bari
Università Degli Studi Di Bari Aldo Moro
Izquierdo, Guillermo Ayuso
Spain, Sevilla
Hospital Universitario Virgen Macarena
Lugaresi, Alessandra
Italy, Chieti
University of G. D'annunzio Chieti and Pescara
Grand'Maison, François
Canada, Greenfield Park
Hôpital Charles-le Moyne
Hupperts, Raymond M.M.
Netherlands, Sittard
Orbis Medical Center
Oreja-Guevara, Celia
Spain, Madrid
Hospital Clínico San Carlos
Bergamaschi, Roberto
Italy, Pavia
Irccs Fondazione Mondino
Iuliano, Gerardo
Italy, Salerno
Ospedali Riuniti Di Salerno
Alroughani, Raed A.
Kuwait, Safat
Al-amiri Hospital
van Pesch, Vincent
Belgium, Brussels
Cliniques Universitaires Saint-luc
Amato, Maria Pia
Italy, Florence
Università Degli Studi Di Firenze
Slee, Mark
Australia, Adelaide
Flinders University
Verheul, Freek A.M.
Netherlands, Gouda
Groen Hart Ziekenhuis
Fernández-Bolaños, Ricardo
Spain, Sevilla
Hospital Universitario de Valme
Fiol, Marcela Paula
Argentina, Buenos Aires
Fundacion Para la Lucha Contra Las Enfermedades Neurologicas de la Infancia
Spitaleri, Daniele Litterio A.
Italy, Avellino
Aorn San Giuseppe Moscati
Cristiano, Edgardo
Argentina, Buenos Aires
Instituto Universitario Del Hospital Italiano de Buenos Aires
Gray, Orla M.
United Kingdom, Portadown
Craigavon Area Hospital
Cabrera-Gömez, José Antonio
Cuba, Havana
Centro Internacional de Restauración Neurológica
Shaygannejad, Vahid
Iran, Isfahan
Al-zahra Hospital
Herbert, Joseph
United States, New York
Nyu Langone Orthopedic Hospital
Vucic, Steve
Australia, Sydney
Westmead Hospital
Needham, Merrilee
Australia, Sydney
Royal North Shore Hospital
Petkovska-Boskova, Tatjana
North Macedonia, Skopje
Clinic of Neurology Clinical Center
Sirbu, Carmen Adella
Romania, Bucharest
Central Military Hospital, Bucharest
Duquette, Pierre Pascal
Canada, Montreal
Hôpital Notre-dame
Girard, Marc
Canada, Montreal
Hôpital Notre-dame
Grammond, Pierre
Canada, Levis
Hotel-dieu de Levis Hospital
Boz, Cavit
Turkey, Trabzon
Karadeniz Technical University
Giuliani, Giorgio
Italy, Macerata
Ospedale Di Macerata
Rio, Maria Edite
Portugal, Porto
Hospital Cuf Porto
Barnett, Michael H.
Australia, Sydney
The University of Sydney
Flechter, Schlomo
Israel, Beer Yacov
Shamir Medical Center
Moore, Fraser G.A.
Canada, Montreal
Sir Mortimer B. Davis Jewish General Hospital
Singhal, Bhim Sen
India, Mumbai
Bombay Hospital and Medical Research Centre
Bacile, Elizabeth Alejandra
Argentina, Cordoba
Instituto Neurociencias Cordoba
Saladino, María Laura
Argentina, Buenos Aires
Ineba
Shaw, Cameron P.
Australia, Geelong
Geelong Hospital
Skromne, Eli
Mexico, Mexico
Hospital Angeles México
Poehlau, Dieter
Germany, Asbach
Kamillus-klinik
Vella, Norbert
United States, Malta
Mater Dei Hospital
Spelman, Tim D.
Australia, Melbourne
Royal Melbourne Hospital
Liew, Danny
Australia, Melbourne
University of Melbourne
Kilpatrick, Trevor J.
Australia, Melbourne
Royal Melbourne Hospital
Australia, Melbourne
Melbourne Neuroscience Institute
Butzkueven, Helmut
Australia, Melbourne
University of Melbourne
Australia, Melbourne
Royal Melbourne Hospital
Australia, Clayton
Monash University
Paolicelli, Damiano
Unknown Affiliation
Lucchese, Guglielmo
Unknown Affiliation
Iaffaldano, Pietro
Unknown Affiliation
Zwanikken, C.
Unknown Affiliation
De Luca, Giovanna
Unknown Affiliation
Di Tommaso, Valeria
Unknown Affiliation
Travaglini, Daniela
Unknown Affiliation
Pietrolongo, Erika
Unknown Affiliation
di Ioia, Maria
Unknown Affiliation
Farina, Deboah
Unknown Affiliation
Mancinelli, Luca
Unknown Affiliation
Marriott, Mark
Unknown Affiliation
King, J.
Unknown Affiliation
van der Walt, Anneke
Unknown Affiliation
Skibina, Olga G.
Unknown Affiliation
Haartsen, Jodi
Unknown Affiliation
Chamorro, B.
Unknown Affiliation
Petersen, Thor K.
Unknown Affiliation
Cartechini, Elisabetta
Unknown Affiliation
Pucci, Eugenio
Unknown Affiliation
William, D.
Unknown Affiliation
Dark, L.
Unknown Affiliation
Correale, Jorge
Unknown Affiliation
Ysrraelit, C.
Unknown Affiliation
den Braber-Moerland, Leontien
Unknown Affiliation
Jaacks, G.
Unknown Affiliation
Laffue, A.
Unknown Affiliation
Fernanda Páez, M.
Unknown Affiliation
Muñoz, Delicias
Unknown Affiliation
Oleschko Arruda, W.
Unknown Affiliation
Paine, Mark A.
Unknown Affiliation
Vella, M.
Unknown Affiliation
Vetere, S.
Unknown Affiliation
Statistics
Citations: 150
Authors: 82
Affiliations: 45
Identifiers
Doi:
10.1093/brain/awt281
e-ISSN:
14602156
Research Areas
Health System And Policy
Study Design
Cohort Study
Participants Gender
Male
Female