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AFRICAN RESEARCH NEXUS

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Infliximab for Paradoxical Reactions in Pediatric Central Nervous System Tuberculosis

Journal of the Pediatric Infectious Diseases Society, Volume 10, No. 12, Year 2021

Paradoxical reactions in central nervous system tuberculosis (CNS-TB) are associated with significant morbidity and mortality. We describe 4 HIV-uninfected children treated for CNS-TB with severe paradoxical reactions unresponsive to corticosteroids. All made recovery after treatment with infliximab, highlighting the safety and effectiveness of infliximab for this complication, and need for prospective trials.

Abo, Yara Natalie
1. Australia, Melbourne Royal Children's Hospital, Melbourne
Curtis, Nigel C.
1. Australia, Melbourne Royal Children's Hospital, Melbourne
2. Australia, Melbourne University of Melbourne
3. Australia, Melbourne Murdoch Children's Research Institute
Osowicki, Joshua
1. Australia, Melbourne Royal Children's Hospital, Melbourne
2. Australia, Melbourne University of Melbourne
3. Australia, Melbourne Murdoch Children's Research Institute
Haeusler, Gabrielle
1. Australia, Melbourne Royal Children's Hospital, Melbourne
2. Australia, Melbourne University of Melbourne
3. Australia, Melbourne Peter Maccallum Cancer Centre
Purcell, Rachael
1. Australia, Melbourne Royal Children's Hospital, Melbourne
Kadambari, Seilesh
1. Australia, Melbourne Royal Children's Hospital, Melbourne
de Wachter, Matthias
1. Belgium, Edegem Universitair Ziekenhuis Antwerpen
Vanden Driessche, Koen
1. Belgium, Edegem Universitair Ziekenhuis Antwerpen
2. Netherlands, Nijmegen Radboud University Medical Center
3. South Africa, Cape Town Stellenbosch University, Faculty of Medicine and Health Sciences
Dekeyzer, Sven
1. Belgium, Edegem Universitair Ziekenhuis Antwerpen
Coleman, Lee
1. Australia, Melbourne Royal Children's Hospital, Melbourne
Crawford, Nigel W.
1. Australia, Melbourne Royal Children's Hospital, Melbourne
Graham, Steve
1. Australia, Melbourne University of Melbourne
2. Australia, Melbourne Murdoch Children's Research Institute
Marais, Ben J.
1. Australia, Sydney The Children's Hospital at Westmead
2. Australia, Sydney Faculty of Medicine and Health
Gwee, Amanda
1. Australia, Melbourne Royal Children's Hospital, Melbourne
2. Australia, Melbourne University of Melbourne
3. Australia, Melbourne Murdoch Children's Research Institute

AFRICAN RESEARCH NEXUS

Infliximab for Paradoxical Reactions in Pediatric Central Nervous System Tuberculosis

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African Research Nexus

Useful Links

AFRICAN RESEARCH NEXUS

Infliximab for Paradoxical Reactions in Pediatric Central Nervous System Tuberculosis

Description

Authors & Co-Authors

Disclaimer

African Research Nexus

Useful Links