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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The role of radiation therapy in pediatric mucoepidermoid carcinomas of the salivary glands
Journal of Pediatrics, Volume 162, No. 4, Year 2013
Notification
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Description
Objective: To investigate the role of radiation therapy in rare salivary gland pediatric mucoepidermoid carcinoma (MEC). Study design: A French multicenter retrospective study (level of evidence 4) of children/adolescents treated for MEC between 1980 and 2010 was conducted. Results: Median age of the 38 patients was 14 years. Parotid subsite, low-grade, and early primary stage tumors were encountered in 81%, 82%, and 68% of cases, respectively. All except 1 patient were treated by tumoral surgical excision, and 53% by neck dissection (80% of high grades). Postoperative radiation therapy and chemotherapy were performed in 29% and 11% of cases. With a median 62-month follow-up, overall survival and local control rates were 95% and 84%, respectively. There was 1 nodal relapse. Lower grade and early stage tumors had better survival. Postoperative radiation therapy and chemotherapy were associated with similar local rates. Patients with or without prior cancer had similar outcomes. Conclusions: Pediatric salivary gland MEC carries a good prognosis. Low-intermediate grade, early-stage tumors should be treated with surgery alone. Neck dissection should be performed in high-grade tumors. Radiation therapy should be proposed for high grade and/or advanced primary stage MEC. For high-grade tumors without massive neck involvement, irradiation volumes may be limited to the primary area, given the risk of long-term side effects of radiation therapy in children. Pediatric MEC as second cancers retain a similar prognosis. Long-term follow-up is needed to assess late side effects and second cancers. © 2013 Mosby Inc.
Authors & Co-Authors
Thariat, Juliette O.
France, Nice
Université Côte D'azur
Vedrine, Pierre Olivier
France, Cannes
Hôpital Les Broussailles
Temam, Stephane
France, Villejuif
Institut de Cancerologie Gustave Roussy
Ali, Ali M.
Egypt, Sohag
Faculty of Medicine
Orbach, Daniel H.
France, Paris
Institut Curie
Odin, Guillaume
France, Nice
Centre Hospitalier Universitaire de Nice
Makeieff, Marc
France, Montpellier
Centre Hospitalier Universitaire de Montpellier
Nicollas, Richard
France, Marseille
Ap-hm Assistance Publique - Hôpitaux de Marseille
Penicaud, Martin
France, Marseille
Ap-hm Assistance Publique - Hôpitaux de Marseille
Toussaint, Bruno
France, Nancy
Chu de Nancy
Vergez, Sebastien
France, Toulouse
Chu de Toulouse
Laprie, Anne
France, Toulouse
Institut Claudius Regaud
Rives, Michel
France, Toulouse
Institut Claudius Regaud
Montagne, Karine
France, Nancy
Chu de Nancy
Teissier, Natacha
France, Paris
Hôpital Robert-debré Ap-hp
Castillo, Laurent
France, Nice
Centre Hospitalier Universitaire de Nice
Statistics
Citations: 37
Authors: 16
Affiliations: 12
Identifiers
Doi:
10.1016/j.jpeds.2012.09.045
ISSN:
00223476
e-ISSN:
10976833
Research Areas
Cancer
Health System And Policy
Maternal And Child Health
Study Design
Cohort Study