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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Therapeutic potential of fucoidan in myocardial ischemia
Journal of Cardiovascular Pharmacology, Volume 58, No. 6, Year 2011
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Description
Fucoidan, a sulfated polysaccharide extracted from brown seaweed, is a candidate for the treatment of ischemic diseases. The aim of this study was to measure the therapeutic potential of fucoidan in a rat model of myocardial ischemia-reperfusion injury. Forty rats were submitted to myocardial ischemia-reperfusion injury by transient occlusion of the left coronary artery. Rats were then randomized into 2 groups: fucoidan (5 mg/kg, intramuscularly; n = 20) or control (saline intramuscularly; n = 20) was administered 1 hour before injury and daily thereafter for 1 month. At 1 month, plasma levels of stromal cell-derived factor-1α (SDF-1α) were assessed by enzyme-linked immunosorbent assay kit. Hearts were evaluated by histoimmunochemistry. Fucoidan induced significant antifibrotic effects, reducing the infarct scar size by almost 30% on Sirius red-stained sections (9.45% ± 4.27% vs. 13% ± 5.67% in controls; P = 0.03). Vascular density in the fucoidan group (α-actin, RECA-1, or lectin BS1 stained) was increased by 40% (2.18 ± 0.79 mm vs. 1.49 ± 0.42 mm in controls ×200; P = 0.001). Plasma SDF-1α at 1 month was not significantly different between the 2 groups. However, increased immunostaining density of SDF-1α and vascular endothelial growth factor in fibrotic ischemic tissues was observed in fucoidan-treated animals versus controls. In conclusion, fucoidan enhanced tissue repair in myocardial ischemia-reperfusion by promoting revascularization (in situ vascular endothelial growth factor and SDF-1α overexpression) and limiting fibrosis. Consequently, fucoidan may be useful for myocardial ischemic patients. © 2011 Lippincott Williams & Wilkins.
Authors & Co-Authors
Manzo-Silberman, Stephane
France, Paris
Inserm
France, Paris
Hopital Cochin Ap-hp
Louedec, Liliane
France, Paris
Inserm
Meilhac, Olivier
France, Paris
Inserm
Letourneur, Didier
France, Paris
Inserm
Michel, Jean Baptiste L.
France, Paris
Inserm
Elmadbouh, Ibrahim
France, Paris
Inserm
Egypt, Shibin el Kom
Menoufia University Faculty of Medicine
Statistics
Citations: 22
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1097/FJC.0b013e3182308c64
ISSN:
01602446
e-ISSN:
15334023
Research Areas
Violence And Injury