Fast scanning calorimetry: Sublimation thermodynamics of low volatile and thermally unstable compounds

Fast scanning calorimetry (FSC) was applied for measurements of the sublimation rates of theophylline, caffeine and anthraquinone as reference compounds. In comparison to conventional vapor pressure determination techniques, this method requires only nano-gram-size samples. The increased surface to volume ratio allows for very high sublimation rates and makes the sublimation process dominant over a possible decomposition. Experimental conditions and data treatment have been elaborated and validated by comparison with reliable literature data. The FSC method “opens a new door” for reliable experimental determination of vapor pressures and sublimation enthalpies for very low volatile and thermally unstable compounds like bio-relevant molecules. © 2019 Elsevier B.V.