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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Cardiovascular risk factors and metabolic syndrome in people with established psychotic illnesses: Baseline data from the IMPaCT randomized controlled trial
Psychological Medicine, Volume 45, No. 12, Year 2015
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Description
Background The aims of the study were to determine the prevalence of cardiometabolic risk factors and establish the proportion of people with psychosis meeting criteria for the metabolic syndrome (MetS). The study also aimed to identify the key lifestyle behaviours associated with increased risk of the MetS and to investigate whether the MetS is associated with illness severity and degree of functional impairment. Method Baseline data were collected as part of a large randomized controlled trial (IMPaCT RCT). The study took place within community mental health teams in five Mental Health NHS Trusts in urban and rural locations across England. A total of 450 randomly selected out-patients, aged 18-65 years, with an established psychotic illness were recruited. We ascertained the prevalence rates of cardiometabolic risk factors, illness severity and functional impairment and calculated rates of the MetS, using International Diabetes Federation (IDF) and National Cholesterol Education Program Third Adult Treatment Panel criteria. Results High rates of cardiometabolic risk factors were found. Nearly all women and most men had waist circumference exceeding the IDF threshold for central obesity. Half the sample was obese (body mass index ≥ 30 kg/m2) and a fifth met the criteria for type 2 diabetes mellitus. Females were more likely to be obese than males (61% v. 42%, p < 0.001). Of the 308 patients with complete laboratory measures, 57% (n = 175) met the IDF criteria for the MetS. Conclusions In the UK, the prevalence of cardiometabolic risk factors in individuals with psychotic illnesses is much higher than that observed in national general population studies as well as in most international studies of patients with psychosis. © Cambridge University Press 2015 This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited..
Authors & Co-Authors
Lally, John
United Kingdom, London
King's College London
United Kingdom, London
South London and Maudsley Nhs Foundation Trust
Ismail, Khalida A.
United Kingdom, London
King's College London
United Kingdom, London
King's College Hospital Nhs Foundation Trust
Onagbesan, Okanlawon Mohammed
United Kingdom, London
Nihr Maudsley Biomedical Research Centre
Fung, Catherine
United Kingdom, London
King's College London
Stahl, Daniel R.
United Kingdom, London
King's College London
David, Anthony S.
United Kingdom, London
King's College London
Murray, Robin M.
United Kingdom, London
King's College London
United Kingdom, London
South London and Maudsley Nhs Foundation Trust
Gaughran, Fiona P.
United Kingdom, London
King's College London
United Kingdom, London
South London and Maudsley Nhs Foundation Trust
Statistics
Citations: 106
Authors: 8
Affiliations: 7
Identifiers
Doi:
10.1017/S0033291715000562
ISSN:
00332917
Research Areas
Health System And Policy
Mental Health
Noncommunicable Diseases
Study Design
Randomised Control Trial
Cross Sectional Study
Study Approach
Quantitative
Participants Gender
Male
Female