Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
TGF-β
1
released from activated platelets can induce TNF-stimulated human brain endothelium apoptosis: A new mechanism for microvascular lesion during cerebral malaria
Journal of Immunology, Volume 176, No. 2, Year 2006
Notification
URL copied to clipboard!
Description
Platelets have recently been shown to accumulate in brain microvessels of patients with cerebral malaria and to modulate the binding of Plasmodium falciparum-infected red cells to human brain endothelium in vitro. In the present study we used a platelet-endothelial cell coculture model to investigate the mechanisms by which platelets modify the function of human brain microvascular endothelial cells (HBEC). Platelets were found to have a proapoptotic effect on TNF-activated HBEC, and this was contact-dependent, as inhibiting platelet binding prevented endothelial cell killing. We also showed that the supernatant of thrombin-activated platelets killed TNF-stimulated HBEC and that TGF-β1 was the main molecule involved in eedothelial cell death, because its inhibition completely abrogated the activated-platelet supernatant effect. Our data illustrate another aspect of the duality of TGF-β1 in malaria and may provide new insights into the pathogenesis of cerebral malaria. Copyright © 2006 by The American Association of Immunologists, Inc.
Authors & Co-Authors
Wassmer, Samuel Crocodile
Unknown Affiliation
de Souza, Joseph Brian
Unknown Affiliation
Frére, Corinne
Unknown Affiliation
Candal, Francisco J.
Unknown Affiliation
Juhan-Vague, Irène
Unknown Affiliation
Grau, Georges Emile Raymond
Unknown Affiliation
Statistics
Citations: 86
Authors: 6
Affiliations: 7
Identifiers
Doi:
10.4049/jimmunol.176.2.1180
ISSN:
00221767
Research Areas
Cancer
Infectious Diseases