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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
AUX/LAX genes encode a family of auxin influx transporters that perform distinct functions during arabidopsis development
Plant Cell, Volume 24, No. 7, Year 2012
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Description
Auxin transport, which is mediated by specialized influx and efflux carriers, plays a major role in many aspects of plant growth and development. AUXIN1 (AUX1) has been demonstrated to encode a high-affinity auxin influx carrier. In Arabidopsis thaliana, AUX1 belongs to a small multigene family comprising four highly conserved genes (i.e., AUX1 and LIKE AUX1 [LAX] genes LAX1, LAX2, and LAX3). We report that all four members of this AUX/LAX family display auxin uptake functions. Despite the conservation of their biochemical function cotyledons. We also describe how regulatory and coding sequences of AUX/LAX genes have undergone subfunctionalization based on their distinct patterns of spatial expression and the inability of LAX sequences to rescue aux1 mutant phenotypes, respectively. Despite their high sequence similarity at the protein level, transgenic studies reveal that LAX proteins are not correctly targeted in the AUX1 expression domain. Domain swapping studies suggest that the N-terminal half of AUX1 is essential for correct LAX localization. We conclude that Arabidopsis AUX/LAX genes encode a family of auxin influx transporters that perform distinct developmental functions and have evolved distinct regulatory mechanisms.© 2012 American Society of Plant Biologists. All rights reserved.
Authors & Co-Authors
Péret, Benjamin
United Kingdom, Nottingham
University of Nottingham
Swarup, Kamal
United Kingdom, Nottingham
University of Nottingham
Yang, Yaodong
United States, Ann Arbor
University of Michigan, Ann Arbor
Casimiro, Ilda De Jesús
Spain, Badajoz
Universidad de Extremadura
Beemster, Gerrit T.S.
Belgium, Antwerpen
Universiteit Antwerpen
Laplaze, Laurent
France, Montpellier
Université de Montpellier
Murphy, Angus S.
United States, West Lafayette
Purdue University
Bennett, Malcom J.
United Kingdom, Nottingham
University of Nottingham
Statistics
Citations: 315
Authors: 8
Affiliations: 10
Identifiers
Doi:
10.1105/tpc.112.097766
ISSN:
10404651