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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
mathematics
Identification and modeling of calcium dynamics in cardiac myocytes
Simulation Practice and Theory, Volume 8, No. 1-2, Year 2000
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Description
Calcium plays an essential role as a messenger and as a factor in cardiac contraction. In the present study, a model for Ca2+ handling in cardiac cells is presented. After the identification of the sarcoplasmic reticulum (SR) parameters, the SERCA pump and ryanodine channels activities, a comparison is made between experimental and calculated responses. The model's parameters were identified using optimization methods. This identification is based on the response of the digitonin permeabilized cells. The model deals with the dynamics of the calcium exchange between the different compartments of the cell. Cell compartments involved are the SR, the cytosol and the extra-cellular medium. The different components of the mathematical models are discussed and compared. The modeling and simulation are run within Ψlab, 1 a freeware for modeling and simulation of dynamic systems. © 2000 Elsevier Science B.V. All rights reserved.
Authors & Co-Authors
Hamam, Yskandar M.
Unknown Affiliation
Pavoine, Catherine
France, Paris
Inserm
Statistics
Citations: 7
Authors: 2
Affiliations: 1
Identifiers
Doi:
10.1016/S0928-4869(00)00012-4
ISSN:
09284869
Research Areas
Noncommunicable Diseases