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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The sick placenta - The role of malaria
Placenta, Volume 25, No. 5, Year 2004
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Description
The human placenta is an ideal site for the accumulation of Plasmodium falciparum malaria parasites, and as a consequence serious health problems arise for the mother and her baby. The pathogenesis of placental malaria is only partially understood, but it is clear that it leads to a distinct epidemiological pattern of malaria during pregnancy. The objectives of this review are: (1) To review recent data on the epidemiology of malaria in pregnancy, with emphasis on placental malaria; (2) to describe the pathological changes and immunological factors related to placental malaria; and (3) to discuss briefly the functional consequences of this infection for the mother and her baby. The review attempts to bring together local events at the maternal-fetal interface which encompass immunological and pathological processes which relate to the epidemiological pattern of malaria in pregnancy in areas of both high and low malaria transmission. An integrated understanding of the epidemiological, immunological and pathological processes must be achieved in order to understand how to control malaria in pregnancy. The yearly exposure of at least 50 million pregnancies to malaria infection makes it the commonest and most recurrent parasitic infection directly affecting the placenta. These statistics and our limited understanding of its pathogenesis suggest the research priorities on this subject. © 2003 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Brabin, Bernard J.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Netherlands, Amsterdam
Universiteit Van Amsterdam
Romagosa, Cleofé
Spain, Barcelona
Universitat de Barcelona
Abdelgalil, S.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Menéndez, Clara
Spain, Barcelona
Hospital Clinic Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Verhoeff, Francine H.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
McGready, R. M.
Thailand, Mae Sod
Shoklo Malaria Research Unit
Thailand, Nakhon Pathom
Mahidol University
United Kingdom, Oxford
John Radcliffe Hospital
Fletcher, K. Alexander
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Owens, Stephen
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
D'Alessandro, Umberto
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Nosten, François Henry
Thailand, Mae Sod
Shoklo Malaria Research Unit
Thailand, Nakhon Pathom
Mahidol University
United Kingdom, Oxford
John Radcliffe Hospital
Fischer, Philip R.
United States, Rochester
Mayo Clinic
Ordi, J.
Spain, Barcelona
Universitat de Barcelona
Statistics
Citations: 363
Authors: 12
Affiliations: 10
Identifiers
Doi:
10.1016/j.placenta.2003.10.019
ISSN:
01434004
Research Areas
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health