Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Parent-offspring transmission of adipocytokine levels and their associations with metabolic traits
PLoS ONE, Volume 6, No. 4, Article e18182, Year 2011
Notification
URL copied to clipboard!
Description
Adipose tissue secreted cytokines (adipocytokines) have significant effects on the physiology and pathology of human metabolism relevant to diabetes and cardiovascular disease. We determined the relationship of the pattern of these circulating hormones with obesity-related phenotypes and whether such pattern is transmitted from parent to offspring. A combined total of 403 individuals from 156 consenting Saudi families divided into initial (119 families with 123 adults and 131 children) and replication (37 families with 58 adults and 91 children) cohorts were randomly selected from the RIYADH Cohort study. Anthropometrics were evaluated and metabolic measures such as fasting serum glucose, lipid profiles, insulin, leptin, adiponectin, resistin, tumor necrosis factor alpha (TNFα), activated plasminogen activator inhibitor 1 (aPAI1), high sensitivity C-reactive protein (hsCRP) and angiotensin II were also assessed. Parent-offspring regressions revealed that with the exception of hsCRP, all hormones measured showed evidence for significant inheritance. Principal component (PC) analysis of standardized hormone levels demonstrated surprising heritability of the three most common axes of variation. PC1, which explained 21% of the variation, was most strongly loaded on levels of leptin, TNFα, insulin, and aPAI1, and inversely with adiponectin. It was significantly associated with body mass index (BMI) and phenotypically stronger in children, and showed a heritability of ~50%, after adjustment for age, gender and generational effects. We conclude that adipocytokines are highly heritable and their pattern of co-variation significantly influences BMI as early as the pre-teen years. Investigation at the genomic scale is required to determine the variants affecting the regulation of the hormones studied. © 2011 Al-Daghri et al.
Authors & Co-Authors
Al-Daghri, N. Mohammad
Saudi Arabia, Riyadh
College of Sciences
Al-Attas, Omar Salem
Saudi Arabia, Riyadh
College of Sciences
Alokail, Majed Saleh
Saudi Arabia, Riyadh
College of Sciences
Alkharfy, Khalid Mohammad
Saudi Arabia, Riyadh
College of Pharmacy
Yakout, Sobhy M.
Saudi Arabia, Riyadh
College of Sciences
Sabico, Shaun
Saudi Arabia, Riyadh
College of Sciences
Gibson, Greg C.
United States, Atlanta
Georgia Institute of Technology
Chrousos, George Panagiotis
Saudi Arabia, Riyadh
College of Sciences
Greece, Athens
School of Medicine
Kumar, Sudhesh
United Kingdom, Coventry
Warwick Medical School
Statistics
Citations: 49
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1371/journal.pone.0018182
e-ISSN:
19326203
Research Areas
Cancer
Maternal And Child Health
Noncommunicable Diseases
Study Design
Cohort Study
Study Approach
Quantitative