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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Phylogenetic analysis of human parvovirus B19, indicating two subgroups of genotype 1 in Vietnamese patients
Journal of General Virology, Volume 87, No. 10, Year 2006
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Description
Recently, three distinct genotypes (1, 2 and 3) of human parvovirus B19 (B19) have been identified. However, the characteristics and distribution of B19 genotypes in Vietnam have not been investigated. Phylogenetic analysis using 49 subgenomic NS1/VP1 u regions and two coding NS1-VP1/VP2 regions has been applied to investigate the prevalence of B19 genotypes in Vietnamese patients co-infected with Hepatitis B virus. Genetic analysis of the subgenomic NS1/VP1 u region of B19 revealed that two genotypes of B19 were identified in these populations, with predominance of genotype 1 (47/49,96 %) followed by genotype 2 (2/49, 4%), but not genotype 3. Further, phylogenetic analysis of subgenomic B19 genomes revealed two major subgroups within genotype 1 (B19-1A and B19-1B) with an estimated nucleotide difference of >5% between each subgroup, forming different branches. The mean percentage of amino acid variation between subgroup B19-1A and B19-1B was >2% of the NS1, VP1 and VP2 proteins. Our results indicated that two of the three known genotypes of B19 were present in Vietnamese patients, with genotype 1 predominating, and that this genotype can be classified into at least two subgroups, B19-1A and B19-1B. © 2006 SGM.
Authors & Co-Authors
Toan, Nguyen Linh
Germany, Tubingen
Universitätsklinikum Und Medizinische Fakultät Tübingen
Germany, Tubingen
Eberhard Karls Universität Tübingen
Duechting, Anja
Germany, Tubingen
Universitätsklinikum Und Medizinische Fakultät Tübingen
Kremsner, Peter G.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Song, Lehuu
Viet Nam, Hanoi
Tran Hung Dao Hospital
Ebinger, Martin
Germany, Tubingen
Eberhard Karls Universität Tübingen
Aberle, Susanne
Germany, Tubingen
Universitätsklinikum Und Medizinische Fakultät Tübingen
Binh, Vu Quoc
Viet Nam, Hanoi
354 Military Hospital
Duy, Dinh Ng
Viet Nam, Hanoi
Tran Hung Dao Hospital
Toressi, Joseph
Australia, Melbourne
University of Melbourne
Kandolf, Reinhard
Germany, Tubingen
Universitätsklinikum Und Medizinische Fakultät Tübingen
Bock, C. Thomas
Germany, Tubingen
Universitätsklinikum Und Medizinische Fakultät Tübingen
Statistics
Citations: 71
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.1099/vir.0.82037-0
ISSN:
00221317
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study