Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Chitosan-sodium lauryl sulfate nanoparticles as a carrier system for the in vivo delivery of oral insulin
AAPS PharmSciTech, Volume 12, No. 3, Year 2011
Notification
URL copied to clipboard!
Description
The present work explores the possibility of formulating an oral insulin delivery system using nanoparticulate complexes made from the interaction between biodegradable, natural polymer called chitosan and anionic surfactant called sodium lauryl sulfate (SLS). The interaction between chitosan and SLS was confirmed by Fourier transform infrared spectroscopy. The nanoparticles were prepared by simple gelation method under aqueous-based conditions. The nanoparticles were stable in simulated gastric fluids and could protect the encapsulated insulin from the GIT enzymes. Additionally, the in vivo results clearly indicated that the insulin-loaded nanoparticles could effectively reduce the blood glucose level in a diabetic rat model. However, additional formulation modifications are required to improve insulin oral bioavailability. © 2011 American Association of Pharmaceutical Scientists.
Authors & Co-Authors
Elsayed, Amani M.
Sudan, Wad Medani
University of Gezira
Saudi Arabia, Taif
Taif University
Al Remawi, Mayyas M.A.
Saudi Arabia, Taif
Taif University
Qinna, Nidal A.
Jordan, Amman
University of Petra
Farouk, Asim
Sudan, Wad Medani
University of Gezira
Al-Sou'od, Khaldoun A.
Jordan, Mafraq
Al Al-bayt University
Badwan, Adnan Ali
Jordan
Subsidiary of the Jordanian Pharmaceutical Manufacturing Co.
Statistics
Citations: 63
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.1208/s12249-011-9647-5
e-ISSN:
15309932
Research Areas
Health System And Policy