Significance of Serum Survivin and -31G/C Gene Polymorphism in the Early Diagnosis of Breast Cancer in Egypt

The majority of breast cancer cases are discovered in later disease stages, thus affecting survival rate. We studied the impact of survivin -31 G/C single nucleotide polymorphism and its serum level alteration. Minor allele C and the GC + CC genotype occurred more frequently in breast cancer patients; further, increased breast cancer risk with associated with elevated serum survivin level. These data could help in early diagnosis and understanding of the pathogenesis of breast cancer.