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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Prevalence of hepatic abnormalities in a cohort of Egyptian children with type 1 diabetes mellitus
Pediatric Diabetes, Volume 11, No. 7, Year 2010
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Description
Background and aim: Children with type 1 diabetes mellitus (T1DM) are frequently investigated for hepatic abnormalities. This study was carried out to report on the prevalence of hepatic abnormalities in diabetic children and adolescents and to highlight the possible etiology and appropriate management.Methods: The study included 692 children (333 were males) with T1DM attending the Diabetes Unit at Cairo University Pediatric Hospital. Their mean age was 9.65 ± 4.18 yr. All children were subjected to clinical examination for hepatomegaly, determination of alanine aminotransferase (ALT) and antibodies to hepatitis C virus (anti-HCV), and abdominal ultrasonography. All children with clinical, laboratory or ultrasound abnormality were counseled about proper glycemic control and followed up. If abnormalities persisted, more detailed investigations were carried out. HCV RNA was done for anti-HCV positive children.Results: Sixty (8.7%) were found to have one or more abnormalities: clinical hepatomegaly in 13 (1.9%), elevated ALT in 27 (3.9%), anti-HCV in 25 (3.6%) and abnormal hepatic ultrasound in 31 (4.5%). Forty percent of anti-HCV positive children were HCV-RNA positive. Glycogenic hepatopathy was diagnosed in three cases by liver biopsy. Abnormalities were reversible in 37/60 after proper glycemic control.Conclusion: Although diabetic children are at risk of acquisition of HCV, poor glycemic control is the key factor that predisposes to hepatomegaly, elevated ALT and abnormal ultrasound findings. A 4 to 8-wk therapeutic trial of proper glycemic control is recommended prior to more invasive diagnostic procedures. © 2009 John Wiley & Sons A/S.
Authors & Co-Authors
El Karaksy, H. M.
Egypt, Giza
Cairo University
Anwar, G. H.
Egypt, Giza
Cairo University
Esmat, Gamal
Egypt, Giza
Cairo University
Mansour, Samah
Egypt, Giza
Cairo University
Sabry, Magda
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
Helmy, Heba M.
Egypt, Giza
Cairo University
El-Hennawy, Ahmed Mohamed Yehia
Egypt, Giza
Cairo University
Fouad, Hanan Mina
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
Statistics
Citations: 35
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.1111/j.1399-5448.2009.00627.x
ISSN:
1399543X
e-ISSN:
13995448
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study