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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
HIV-induced immunodeficiency and mortality from AIDS-defining and non-AIDS-defining malignancies
AIDS, Volume 22, No. 16, Year 2008
Notification
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Description
Objective: To evaluate deaths from AIDS-defining malignancies (ADM) and non-AIDSdefining malignancies (nADM) in the D:A:D Study and to investigate the relationship between these deaths and immunodeficiency. Design: Observational cohort study. Methods: Patients (23 437)were followed prospectively for 104 921 person-years.We used Poisson regression models to identify factors independently associated with deaths from ADM and nADM. Analyses of factors associated with mortality due to nADMwere repeated after excludingnADMknown to be associated with a specific risk factor. Results: Three hundred five patients died due to a malignancy, 298 prior to the cutoff for this analysis (ADM: n=110; nADM: n=188). The mortality rate due to ADM decreased from 20.1/1000 person-years of follow-up [95% confidence interval (CI) 14.4, 25.9] when the most recent CD4 cell count was <50 cells/μl to 0.1 (0.03, 0.3)/ 1000 person-years of follow-up when the CD4 cell count was more than 500 cells/μl; the mortality rate from nADM decreased from 6.0 (95% CI 3.3, 10.1) to 0.6 (0.4, 0.8) per 1000 person-years of follow-up between these two CD4 cell count strata. In multivariable regression analyses, a two-fold higher latest CD4 cell count was associated with a halving of the risk of ADM mortality. Other predictors of an increased risk of ADM mortality were homosexual risk group, older age, a previous (non-malignancy) AIDS diagnosis and earlier calendar years. Predictors of an increased risk of nADM mortality included lower CD4 cell count, older age, current/ex-smoking status, longer cumulative exposure to combination antiretroviral therapy, active hepatitis B infection and earlier calendar year. Conclusion: The severity of immunosuppression is predictive of death from both ADM and nADM in HIV-infected populations. © 2008 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Authors & Co-Authors
D'Arminio Monforte, Antonella D.
Italy, Milan
Ospedale San Paolo
Pradier, Christian
France, Nice
Centre Hospitalier Universitaire de Nice
Switzerland, Zurich
Swiss Hiv Cohort Study
Weber, Rainer
Switzerland, Zurich
Universitatsspital Zurich
Reiss, Peter
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Bonnet, Fabrice
France, Bordeaux
Université de Bordeaux
Kirk, Ole
Denmark, Copenhagen
Københavns Universitet
Denmark, Copenhagen
Eurosida
Law, Matthew G.
Australia, Kensington
The Kirby Institute
de Wit, Stéphane A.
Belgium, Brussels
Centre Hospitalier Universitaire Saint Pierre, Brussels
Friis-Möller, Nina
Denmark, Copenhagen
Københavns Universitet
Phillips, Andrew N.
United Kingdom, London
Ucl Medical School
Denmark, Copenhagen
Eurosida
Sabin, Caroline Anne
United Kingdom, London
Ucl Medical School
Lundgren, Jens D.
Denmark, Copenhagen
Københavns Universitet
Denmark, Copenhagen
Eurosida
Collins, Simon
Unknown Affiliation
Loeliger, Edde
Unknown Affiliation
Tressler, Randall L.
Unknown Affiliation
Weller, Ian V.D.
Unknown Affiliation
Rickenbach, Martin
Switzerland, Zurich
Swiss Hiv Cohort Study
Krum, Eric A.
Unknown Affiliation
Gras, Luuk A.J.
Unknown Affiliation
Balestre, Eric
Unknown Affiliation
Fontas, Éric
Unknown Affiliation
Torres, Ferran L.
France, Bordeaux
Université de Bordeaux
Petoumenos, Kathy
Unknown Affiliation
Kjaer, Jesper
Unknown Affiliation
De Wolf, Frank
Unknown Affiliation
Bos, Jeannet C.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Geerlings, Suzanne Eugenie
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Lange, Joep M.A.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
van der Meer, Jan T.M.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
van der Poll, Tom
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
van der Valk, Marc
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
van Vonderen, Marit G.A.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
van Vugt, Michèle V.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Wit, Ferdinand W.N.M.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Brinkman, Kees
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Mulder, Jan Willem A.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
van Gorp, E. C.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Van Agtmael, Michiel A.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Perenboom, Roos M.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Richter, Clemens
Unknown Affiliation
Schölvinck, Elisabeth H.
Unknown Affiliation
Kroon, Frank P.
Unknown Affiliation
Verbon, Annelies
Unknown Affiliation
Koopmans, Peter P.
Unknown Affiliation
Keuter, Monique M.
Unknown Affiliation
Post, Frank A.
Unknown Affiliation
van der Ven, André J.A.M.
Unknown Affiliation
van der Ende, Marchina Elisabeth
Unknown Affiliation
Gyssens, I. C.
Unknown Affiliation
den Hollander, Jan G.
Unknown Affiliation
Nouwen, Jan L.
Unknown Affiliation
Rijnders, Bart J.A.
Unknown Affiliation
Bonten, Marc J.M.
Unknown Affiliation
Borleffs, Jan C.C.
Unknown Affiliation
Hoepelman, Ilja M.
Unknown Affiliation
Salamon, Roger L.
Unknown Affiliation
Beylot, Jacques C.
France, Bordeaux
Université de Bordeaux
Le Bras, Michel
France, Bordeaux
Université de Bordeaux
Pellegrin, Jean Luc
France, Bordeaux
Université de Bordeaux
Dabis, Franćois Ç.Ois
Unknown Affiliation
Chêne, Geneviève
Unknown Affiliation
Jacqmin-Gadda, Hélène
Unknown Affiliation
Thíébaut, Rodolphe
Unknown Affiliation
Touchard, Dominique
Unknown Affiliation
Morlat, Philippe
France, Bordeaux
Université de Bordeaux
Jaubert, Dominique
France, Bordeaux
Université de Bordeaux
Leng, Bernard M.
France, Bordeaux
Université de Bordeaux
Viallard, Jean François
France, Bordeaux
Université de Bordeaux
Tchamgouè, Serge
France, Bordeaux
Université de Bordeaux
Djossou, Félix
France, Bordeaux
Université de Bordeaux
Malvy, Denis Jean Marie
France, Bordeaux
Université de Bordeaux
Taupin, Jean Luc
France, Bordeaux
Université de Bordeaux
Fleury, Hervè J.A.
France, Bordeaux
Université de Bordeaux
Lafon, Marie Édith
France, Bordeaux
Université de Bordeaux
Masquelier, Bernard
France, Bordeaux
Université de Bordeaux
Trimoulet, Pascale
France, Bordeaux
Université de Bordeaux
Taytard, André
France, Bordeaux
Université de Bordeaux
Anderson, Jane
Unknown Affiliation
Watson, Kerrie M.
Unknown Affiliation
Roth, Norman J.
Unknown Affiliation
Bloch, Mark Theo
Unknown Affiliation
Agrawal, Sudhanshu
Unknown Affiliation
Baker, David Alfred
Unknown Affiliation
Carr, Andrew D.
Unknown Affiliation
Cooper, David A.
Unknown Affiliation
Hesse, Karl
Unknown Affiliation
Chuah, John C.P.
Unknown Affiliation
Mallal, Simon Alexander
Unknown Affiliation
Domingo, Pere
France, Bordeaux
Université de Bordeaux
Samb́eat, María Antònia
France, Bordeaux
Université de Bordeaux
Gatell, José Mariá A.
France, Bordeaux
Université de Bordeaux
Codina Jané, C.
France, Bordeaux
Université de Bordeaux
Clumeck, Nathan N.
Unknown Affiliation
Konopnicki, Deborah
Unknown Affiliation
Libois, Agnès
Unknown Affiliation
Payen, Marie Christine
Unknown Affiliation
van Laethem, Yves
Unknown Affiliation
Mocroft, Amanda J.
Denmark, Copenhagen
Eurosida
Vetter, Norbert
Unknown Affiliation
Karpov, Igor Alexandrovich
Unknown Affiliation
Colebunders, Robert Leon
Unknown Affiliation
Nielsen, Jens Ole D.
Unknown Affiliation
Benfield, Thomas Lars
Unknown Affiliation
Gerstoft, Jan
Unknown Affiliation
Katzenstein, Terese Lea
Unknown Affiliation
Hansen, Ann Brit Eg
Unknown Affiliation
Skinhöj, Peter
Unknown Affiliation
Pedersen, Court K.
Unknown Affiliation
Katlama, Christine
Unknown Affiliation
Viard, Jean Paul
Unknown Affiliation
Girard, Pierre Marie
Unknown Affiliation
Vanhems, Philippe V.
Unknown Affiliation
Dietrich, Manfred
Unknown Affiliation
van Lunzen, Jan
Unknown Affiliation
Stellbrink, Hans Jürgen
Unknown Affiliation
Staszewski, Schlomo
Unknown Affiliation
Goebel, Frank Detlef
Unknown Affiliation
Fätkenheuer, Gerd
Unknown Affiliation
Rockstroh, Jürgen Kurt
Unknown Affiliation
Schmidt, Reinhold Ernst
Unknown Affiliation
Kosmidis, John C.
Unknown Affiliation
Mulcahy, Fiona M.
Unknown Affiliation
Turner, David P.J.
Unknown Affiliation
Pollack, Shimon
Unknown Affiliation
Sthoeger, Zed M.
Unknown Affiliation
Maayan, Sholomo L.
Unknown Affiliation
Vella, Stefano
Unknown Affiliation
Gabbuti, Andrea
Unknown Affiliation
Chirianni, Antonio
Unknown Affiliation
Vullo, Vincenzo
Unknown Affiliation
Narciso, Pasquale
Unknown Affiliation
Antinori, Andrea
Italy, Milan
Icona Foundation
Castagna, Antonella
Italy, Milan
Icona Foundation
Hemmer, Robert J.P.
Unknown Affiliation
Staub, Thérèse
Unknown Affiliation
Bruun, Johann Nikolai
Unknown Affiliation
Ormaasen, Vidar
Unknown Affiliation
Horban, Andrzéj
Unknown Affiliation
Boroń-Kaczmarska, Anna
Unknown Affiliation
Beniowski, Marek
Unknown Affiliation
Trocha, Hanna
Unknown Affiliation
Antunes, Francisco
Unknown Affiliation
Mansinho, Kamal
Unknown Affiliation
Maltêz, Fernando Manuel
Unknown Affiliation
Duiculescu, Dan Constantin
Unknown Affiliation
Streinu-Cercel, Adrian
Unknown Affiliation
Rakhmanova, Aza Gasanovna
Unknown Affiliation
Jevtović, Djordje Ljubomir
Unknown Affiliation
González-Lahoz, Juan María
Unknown Affiliation
Soriano, Vicente Vicente
Unknown Affiliation
Clotet, Bonaventura
Unknown Affiliation
Ruíz, Lídia
Unknown Affiliation
Tural, Cristina
Unknown Affiliation
Miró, José María
Unknown Affiliation
Blaxhult, Anders
Unknown Affiliation
Karlsson, Anders Cecilia
Unknown Affiliation
Pehrson, Pehrolov
Unknown Affiliation
Ledergerber, Bruno
Switzerland, Zurich
Swiss Hiv Cohort Study
Francioli, Patrick B.
Switzerland, Zurich
Swiss Hiv Cohort Study
Telenti, Amalio
Switzerland, Zurich
Swiss Hiv Cohort Study
Hirschel, Bernard J.
Switzerland, Zurich
Swiss Hiv Cohort Study
Furrer, Hansjakob Jackob
Switzerland, Zurich
Swiss Hiv Cohort Study
Fisher, Martin J.
United Kingdom, Sussex
Brighton
Johnson, Anne M.
United Kingdom, London
London
Johnson, Margaret A.
United Kingdom, London
London
Weber, Jonathan N.
United Kingdom, London
London
Ha°kanga°rd, Camilla
Unknown Affiliation
Maggiolo, Franco
Italy, Milan
Icona Foundation
Balotta, Claudia
Italy, Milan
Icona Foundation
Bonfanti, Paolo
Italy, Milan
Icona Foundation
Capobianchi, Maria Rosaria
Italy, Milan
Icona Foundation
Ceccherini-Silberstein, Francesca
Italy, Milan
Icona Foundation
Cozzi-Lepri, Alessandro
Italy, Milan
Icona Foundation
De Luca, Andrea
Italy, Milan
Icona Foundation
Gervasoni, Cristina
Italy, Milan
Icona Foundation
Girardi, Enrico
Italy, Milan
Icona Foundation
Lo Caputo, Sergio
Italy, Milan
Icona Foundation
Murri, Rita
Italy, Milan
Icona Foundation
Mussini, Cristina
Italy, Milan
Icona Foundation
Puoti, Massimo
Italy, Milan
Icona Foundation
Torti, Carlo
Italy, Milan
Icona Foundation
Carosi, Giaampiero
Italy, Milan
Icona Foundation
Cauda, Roberto
Italy, Milan
Icona Foundation
Di Perri, Giovanni
Italy, Milan
Icona Foundation
Galli, Massimo
Italy, Milan
Icona Foundation
Iardino, Rosaria
Italy, Milan
Icona Foundation
Ippolito, Giuseppe
Italy, Milan
Icona Foundation
Perno, Carlo Federico
Italy, Milan
Icona Foundation
Scalise, Giorgio
Unknown Affiliation
Riva, Agostino
Unknown Affiliation
Suter, Fredy
Unknown Affiliation
Quirino, Tiziana
Unknown Affiliation
Zoncada, Alessia
Unknown Affiliation
Lazzarin, Adriano
Unknown Affiliation
Rizzardini, Giuliano
Unknown Affiliation
Gori, Andrea
Unknown Affiliation
Ferrari, Carlo C.
Unknown Affiliation
Bruno, R.
Unknown Affiliation
Andreoni, Massimo G.
Unknown Affiliation
Tozzi, Valerio
Unknown Affiliation
Lichtner, Miriam
Unknown Affiliation
Caramello, Pietro
Unknown Affiliation
Orofino, Giancarlo
Unknown Affiliation
Pellizzer, Giampietro P.
Unknown Affiliation
Buonfrate, Dora
Unknown Affiliation
Caissotti, Christophe
Unknown Affiliation
Dellamonica, Pierre
Unknown Affiliation
Durant, Jacques M.
Unknown Affiliation
Roger, Pierre‑Marie
Unknown Affiliation
Battegay, Manuel
Switzerland, Zurich
Swiss Hiv Cohort Study
Bernasconi, Enos
Switzerland, Zurich
Swiss Hiv Cohort Study
Böni, Jürg
Switzerland, Zurich
Swiss Hiv Cohort Study
Bucher, Heíner C.C.
Switzerland, Zurich
Swiss Hiv Cohort Study
Bürgisser, Ph
Switzerland, Zurich
Swiss Hiv Cohort Study
Cattacin, Sandro
Switzerland, Zurich
Swiss Hiv Cohort Study
Cavassini, Matthias
Switzerland, Zurich
Swiss Hiv Cohort Study
Dubs, Rolf W.
Switzerland, Zurich
Swiss Hiv Cohort Study
Egger, Matthias
Switzerland, Zurich
Swiss Hiv Cohort Study
Elzi, Luigia
Switzerland, Zurich
Swiss Hiv Cohort Study
Erb, Peter
Switzerland, Zurich
Swiss Hiv Cohort Study
Fischer, Marek
Switzerland, Zurich
Swiss Hiv Cohort Study
Flepp, Markus J.
Switzerland, Zurich
Swiss Hiv Cohort Study
Fontana, Adriano
Switzerland, Zurich
Swiss Hiv Cohort Study
Gorgievski, Meri
Switzerland, Zurich
Swiss Hiv Cohort Study
Günthard, Hüldrych Fritz
Switzerland, Zurich
Swiss Hiv Cohort Study
Kaiser, Laurent K.
Switzerland, Zurich
Swiss Hiv Cohort Study
Kind, Christian H.
Switzerland, Zurich
Swiss Hiv Cohort Study
Klimkait, Thomas
Switzerland, Zurich
Swiss Hiv Cohort Study
Opravil, Milos
Switzerland, Zurich
Swiss Hiv Cohort Study
Pantaleo, Giuseppe P.
Switzerland, Zurich
Swiss Hiv Cohort Study
Perrin, Luc Henri
Switzerland, Zurich
Swiss Hiv Cohort Study
Piffaretti, Jean Claude L.
Switzerland, Zurich
Swiss Hiv Cohort Study
Rudin, Christoph
Switzerland, Zurich
Swiss Hiv Cohort Study
Schmid, Patrick
Switzerland, Zurich
Swiss Hiv Cohort Study
Schüpbach, Jörg Rg
Switzerland, Zurich
Swiss Hiv Cohort Study
Speck, Roberto F.
Switzerland, Zurich
Swiss Hiv Cohort Study
Trkola, Alexandra
Switzerland, Zurich
Swiss Hiv Cohort Study
Vernazza, Pietro Luigi
Switzerland, Zurich
Swiss Hiv Cohort Study
Yerly, Sabine T.B.D.
Switzerland, Zurich
Swiss Hiv Cohort Study
Statistics
Citations: 257
Authors: 239
Affiliations: 16
Identifiers
Doi:
10.1097/QAD.0b013e3283112b77
ISSN:
02699370
Research Areas
Infectious Diseases
Study Design
Cohort Study
Study Approach
Quantitative