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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Electrocardiographic measures of left ventricular hypertrophy show greater heritability than echocardiographic left ventricular mass: A family study
European Heart Journal, Volume 23, No. 24, Year 2002
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Description
Aims: To assess the heritability (i.e. relative contribution of genetic factors to the variability) of continuous measures of left ventricular hypertrophy determined by electrocardiography and echocardiography. Methods and Results: We studied 955 members of 229 Caucasian families, ascertained through a hypertensive proband. Electrocardiographic measurements were performed manually on resting 12-lead electrocardiograms, and echocardiographic measurements were made on M-mode images. Sex-specific residuals for the left ventricular phenotypes were calculated, adjusted for age, systolic blood pressure, weight, height, waist-hip ratio, and presence of diabetes. Heritability was estimated in two ways: firstly, from familial correlations with adjustment for spouse resemblance; and secondly by using variance components methods with ascertainment correction for proband status. The heritability estimates (given as a range derived from the two methods) were higher for Sokolow-Lyon voltage (39-41%) than for echocardiographic left ventricular mass (23-29%). Electrocardiographic left ventricular mass, Cornell voltage, and Cornell product had heritability estimates of 12-18%, 1925%, and 28-32%, respectively. Conclusions: Genetic factors may explain a substantial proportion of variability in quantitative electrocardiographic and echocardiographic measures of left ventricular hypertrophy. The greater heritability of Sokolow-Lyon voltage suggests that electrocardiographic phenotypes may be particularly important for the molecular investigation of the genetic susceptibility to cardiac hypertrophy. © 2002 The European Society of Cardiology. Published by Elsevier Science Ltd. All rights reserved.
Authors & Co-Authors
Mayosi, Bongani M.
United Kingdom, Oxford
John Radcliffe Hospital
South Africa, Observatory
Groote Schuur Hospital
Keavney, Bernard D.
United Kingdom, Oxford
John Radcliffe Hospital
Kardos, Attila
United Kingdom, Oxford
John Radcliffe Hospital
Davies, C. H.
United Kingdom, Oxford
John Radcliffe Hospital
Ratcliffe, Peter J.
United Kingdom, Oxford
John Radcliffe Hospital
Farrall, Martin
United Kingdom, Oxford
John Radcliffe Hospital
Watkins, Hugh C.
United Kingdom, Oxford
John Radcliffe Hospital
Statistics
Citations: 7
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.1053/euhj.2002.3288
ISSN:
0195668X
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Approach
Quantitative