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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The pharmacogenetics of chemical carcinogenesis
Pharmacogenetics, Volume 2, No. 6, Year 1992
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Description
The human body is endowed with a large number of xenobiotic chemical metabolizing enzymes, a significant proportion of which are polymorphic and thus render one individual at greater or lesser risk than another of chemically-induced disease. All examples of genetic polymorphism of chemical metabolizing enzymes have been reviewed in relation to their potential to activate and detoxicate procarcinogens and promutagens. Many examples are cited whereby phenotype can act as a carcinogenic risk factor. With the availability of a large amount of DNA sequence data for chemical metabolizing enzymes there has emerged a number of polymerase chain reaction (PCR) strategies aimed at discerning one metabolic phenotype or another. This is seen as a very positive and democratic scientific development, widening the franchise for studies of disease risk. Nevertheless, it is argued that, at these early stages with many laboratory-based scientists scarcely familiar with epidemiological study design, a cautious approach should obtain when interpreting single studies. © 1992 Chapman and Hall.
Authors & Co-Authors
Idle, Jeffrey R.
United Kingdom, Newcastle
School of Medical Education
Armstrong, Martin
United Kingdom, Newcastle
School of Medical Education
Boddy, Alan V.
United Kingdom, Newcastle
School of Medical Education
Boustead, Carol
United Kingdom, Newcastle
School of Medical Education
Cholerton, Suzanne
United Kingdom, Newcastle
School of Medical Education
Cooper, Jane
United Kingdom, Newcastle
School of Medical Education
Daly, Ann K.
United Kingdom, Newcastle
School of Medical Education
Ellis, Janice
United Kingdom, Newcastle
School of Medical Education
Gregory, Wendy
United Kingdom, Newcastle
School of Medical Education
Hadidi, Hakam
United Kingdom, Newcastle
School of Medical Education
Jordan, Irbid
Jordan University of Science and Technology
Höfer, Constance
United Kingdom, Newcastle
School of Medical Education
Holt, John
United Kingdom, Newcastle
School of Medical Education
Leathart, Julian
United Kingdom, Newcastle
School of Medical Education
McCracken, Nigel
United Kingdom, Newcastle
School of Medical Education
Monkman, Sophia C.
United Kingdom, Newcastle
School of Medical Education
Painter, John E.
United Kingdom, Newcastle
School of Medical Education
Taber, Heather
United Kingdom, Newcastle
School of Medical Education
Walker, Dianne
United Kingdom, Newcastle
School of Medical Education
Yule, Murray
United Kingdom, Newcastle
School of Medical Education
Statistics
Citations: 65
Authors: 19
Affiliations: 2
Identifiers
Doi:
10.1097/00008571-199212000-00002
ISSN:
0960314X
Research Areas
Cancer
Genetics And Genomics
Noncommunicable Diseases