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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Oestrogen and progesterone receptor concentrations in leiomyoma and normal myometrium
Annals of Clinical Biochemistry, Volume 24, No. 3, Year 1987
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Description
The content of cytoplasmic 17β oestradiol and progesterone receptors in human uterine leiomyoma and normal myometrium in the Negroid population was determined. Eighteen women of reproductive age, at various stages of the menstrual cycle, were included in the study. The serum oestrogen and progesterone concentrations were also measured. This is the first report in the literature in which oestrogen and progesterone receptors in leiomyoma are significantly higher than in normal myometrium P=0·0002). The steroid dependence of the growth of leiomyomas may be related to the steroid receptor level. The presence of persistently high concentrations of oestrogen and progesterone receptors in leiomyoma should be helpful in the treatment of this benign tumour. © 1987, Association for Clinical Biochemistry. All rights reserved.
Authors & Co-Authors
Sadan, Oscar
United Kingdom, Cambridge
Department of Obstetrics and Gynaecology
van Iddekinge, Basil
United Kingdom, Cambridge
Department of Obstetrics and Gynaecology
van Gelderen, Cyril J.
United Kingdom, Cambridge
Department of Obstetrics and Gynaecology
Savage, Nerina
Unknown Affiliation
Becker, P. J.
United Kingdom, London
Medical Research Council
van der Walt, L. André
South Africa, Johannesburg
School of Clinical Medicine
Robinson, Michael F.
South Africa, Johannesburg
Charlotte Maxeke Johannesburg Academic Hospital
Statistics
Citations: 66
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1177/000456328702400304
ISSN:
00045632
e-ISSN:
17581001
Research Areas
Cancer
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Participants Gender
Female