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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Correlation of apparent diffusion coefficient value with prognostic parameters of lung cancer
Journal of Computer Assisted Tomography, Volume 35, No. 2, Year 2011
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Description
PURPOSE: The purpose of this study was to correlate the apparent diffusion coefficient (ADC) value with prognostic parameters of lung cancer. METHODS: Thirty-one patients diagnosed with lung cancer (22 men, 9 women; mean age, 57 years) underwent diffusion-weighted magnetic resonance imaging of the chest using echo-planar imaging sequence with b factors of 0, 300, and 600 s/mm. Apparent diffusion coefficient values were calculated and correlated with tumor grade and size as well as associated mediastinal lymph nodes. Institutional review board approval was obtained for this prospective study. RESULTS: The mean ADC value of small cell lung cancer (1.02 ± 0.30 × 10 mm/s) was significantly different (P = 0.025) from non-small cell lung cancer (1.39 ± 0.47 × 10 mm/s). There was a significant difference in the ADC value between poorly and well-differentiated to moderately differentiated lung cancer (P = 0.03) as well as between patients with N0 and N3 mediastinal lymphadenopathy (P = 0.043). The ADC value of lung cancer correlated with tumor grade (r = -0.481, P = 0.043) and metastatic mediastinal nodes (r = -0.422, P = 0.018). CONCLUSIONS: Apparent diffusion coefficient value of the lung cancer can be considered as a new prognostic parameter. Lower ADC value of the lung cancer is associated with higher pathological tumor grade and metastatic lymph nodes. © 2011 Lippincott Williams & Wilkins, Inc.
Authors & Co-Authors
Abdel Razek, Ahmed Abdel Khalek
Egypt, Mansoura
Faculty of Medicine
Fathy, A.
Egypt, Mansoura
Faculty of Medicine
Gawad, Taha Abdel
Egypt, Mansoura
Faculty of Medicine
Statistics
Citations: 66
Authors: 3
Affiliations: 1
Identifiers
Doi:
10.1097/RCT.0b013e31820ccf73
ISSN:
03638715
Research Areas
Cancer
Study Design
Cohort Study
Participants Gender
Male
Female