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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Evidence for henipavirus spillover into human populations in Africa
Nature Communications, Volume 5, Article 5342, Year 2014
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Description
Zoonotic transmission of lethal henipaviruses (HNVs) from their natural fruit bat reservoirs to humans has only been reported in Australia and South/Southeast Asia. However, a recent study discovered numerous HNV clades in African bat samples. To determine the potential for HNV spillover events among humans in Africa, here we examine well-curated sets of bat (Eidolon helvum, n=44) and human (n=497) serum samples from Cameroon for Nipah virus (NiV) cross-neutralizing antibodies (NiV-X-Nabs). Using a vesicular stomatitis virus (VSV)-based pseudoparticle seroneutralization assay, we detect NiV-X-Nabs in 48% and 3-4% of the bat and human samples, respectively. Seropositive human samples are found almost exclusively in individuals who reported butchering bats for bushmeat. Seropositive human sera also neutralize Hendra virus and Gh-M74a (an African HNV) pseudoparticles, as well as live NiV. Butchering bat meat and living in areas undergoing deforestation are the most significant risk factors associated with seropositivity. Evidence for HNV spillover events warrants increased surveillance efforts. © 2014 Macmillan Publishers Limited. All rights reserved.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4237230/bin/ncomms6342-s1.pdf
Authors & Co-Authors
Schneider, Bradley S.
United States, San Francisco
Metabiota, Inc.
LeBreton, Matthew
United States, San Francisco
Metabiota, Inc.
Bowden, Thomas A.
United Kingdom, Oxford
University of Oxford
Hitchens, Peta Lee
United States, Davis
University of California, Davis
Ramirez, Christina Michelle
United States, Los Angeles
University of California, Los Angeles
Daszak, Peter
United States, New York
Ecohealth Alliance
Mazet, Jonna A.K.
United States, Davis
University of California, Davis
Freiberg, Alexander N.
United States, Galveston
The University of Texas Medical Branch at Galveston
Wolfe, Nathan D.
United States, San Francisco
Metabiota, Inc.
Lee, Benhur
United States, Los Angeles
David Geffen School of Medicine at Ucla
United States, New York
Icahn School of Medicine at Mount Sinai
Statistics
Citations: 125
Authors: 10
Affiliations: 9
Identifiers
Doi:
10.1038/ncomms6342
ISSN:
20411723
Research Areas
Infectious Diseases
Study Locations
Cameroon