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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Analysis of circulating populations of Plasmodium falciparum in mild and severe malaria in two different epidemiological patterns in Madagascar
Tropical Medicine and International Health, Volume 13, No. 11, Year 2008
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Description
Objective: To investigate whether the severity of Plasmodium falciparum attack in endemic areas was associated with the multiplicity of infection (MOI) and/or with a particular genotype(s). Method: In two areas of different malaria transmission pattern in Madagascar (Sainte-Marie - mesoendemic and Tsiroanomandidy - hypoendemic) the number and the proportions of msp-2 genotypes within isolates were determined for each patient using a capillary electrophoresis genotyping method. DNA sequencing was performed to identify the msp-2 allelic family of dominant clones. Results: Eighty six uncomplicated and 33 severe cases were included in Sainte-Marie and 48 uncomplicated and 69 severe cases were included in Tsiroanomandidy. We found no association between the MOI and severity of malaria as the same mean number of msp-2 genotypes was found in isolates from uncomplicated and from severe malaria cases (3.72 and 3.73, respectively, P>0.05). The study of the association of dominant clones with clinical status showed no particular genotype or allelic family associated with malaria severity. Conclusions: Severity of malaria was not associated with higher MOI in our study. Severity did not appear restricted to some particular genotypes either. On the contrary, severe malaria appeared to be caused by very common genotypes in the studied areas. More comprehensive explorations including immunity and genetic factors of the host are needed to acquire new information about this complex condition. © 2008 Blackwell Publishing Ltd.
Authors & Co-Authors
Durand, Rémy
France, Bobigny
Hopital Avicenne
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Ariey, Frédéric
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Cojean, Sandrine
France, Gif-sur-yvette
Université Paris-saclay
Fontanet, A. L.
France, Paris
Institut Pasteur, Paris
Ranaivo, Louise Henriette
Madagascar, Antananarivo
Ministère de la Santé
Ranarivelo, Lanto Alisoa
Madagascar, Antananarivo
Ministère de la Santé
Vonimpaisomihanta, Jeanne Aimée
Madagascar, Antananarivo
Ministère de la Santé
Menard, Didier
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Pietra, Virginio
Madagascar, Antananarivo
Ministère de la Santé
Italy, Rome
Direzione Generale Per la Cooperazione Allo Sviluppo
Le Bras, Jacques L.
France, Paris
Université Paris Cité
Modiano, David
Italy, Rome
Sapienza Università Di Roma
Randrianarivelojosia, Milijaona
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Statistics
Citations: 30
Authors: 12
Affiliations: 10
Identifiers
Doi:
10.1111/j.1365-3156.2008.02156.x
ISSN:
13602276
e-ISSN:
13653156
Research Areas
Genetics And Genomics
Health System And Policy
Infectious Diseases
Study Locations
Madagascar