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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The effect of curcumin on insulin release in rat-isolated pancreatic islets
Angiology, Volume 61, No. 6, Year 2010
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Description
Curcumin exerts a hypoglycemic action and induces heme-oxygenase-1 (HO-1). We evaluated the effect of curcumin on isolated islets of Langerhans and studied whether its action on insulin secretion is mediated by inducible HO-1. Islets were isolated from rats and divided into control islets, islets incubated in different curcumin concentrations, islets incubated in hemin, islets incubated in curcumin and HO inhibitor, stannous mesoporphyrin (SnMP), islets incubated in hemin and SnMP, islets incubated in SnMP only, and islets incubated in 16.7 mmol/L glucose. Heme-oxygenase activity, HO-1 expression, and insulin estimation was assessed. Insulin secretion, HO-1 gene expression and HO activity were significantly increased in islets incubated in curcumin, hemin, and glucose compared with controls. This increase in insulin secretion was significantly decreased by incubation of islets in SnMP. The action of curcumin on insulin secretion from the isolated islets may be, in part, mediated through increased HO-1 gene expression. © 2010 The Author(s).
Authors & Co-Authors
Abdel-Aziz, Mohammed Talaat
Egypt, Cairo
Faculty of Medicine
El-Asmar, Mohamed Farid
Egypt, Cairo
College of Science
El Nadi, Essam G.
Egypt, Cairo
Faculty of Medicine
Wassef, Mohamed Abdel Aziz
Egypt, Cairo
Faculty of Medicine
Ahmed, Hanan Hosni
Egypt, Cairo
Faculty of Medicine
Rashed, Laila Ahmed
Egypt, Cairo
Faculty of Medicine
Obaia, Eman M.
Egypt, Cairo
Faculty of Medicine
Sabry, D. A.
Egypt, Cairo
Faculty of Medicine
Hassouna, Amira Ahmed
Egypt, Cairo
Faculty of Medicine
Abdel Aziz, Ahmed Talaat
Egypt, Cairo
Faculty of Medicine
Statistics
Citations: 39
Authors: 10
Affiliations: 2
Identifiers
Doi:
10.1177/0003319709356424
ISSN:
00033197
Research Areas
Genetics And Genomics