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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Schistosoma mansoni infection: Is it a risk factor for development of hepatocellular carcinoma?
Acta Tropica, Volume 128, No. 3, Year 2013
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Description
The burden of hepatocellular carcinoma (HCC) in Egypt has been increasing with a doubling in the incidence rate in the past 10 years, which necessitates the investigation of the possible risk factors to its development. The present study aimed at investigating the role of Schistosoma mansoni infection as a risk factor for development of HCC. Five hundred parasite free mice were categorized into four groups: Group I (induction of carcinoma by diethylnitrosamine (DEN)), Group II (DEN. +. Infection), Group III (Infection) and Group IV (Control). Groups I and II were further subdivided into 4 subgroups according to the dose of DEN given. Serum samples from each group were examined for levels of tumor markers alpha fetoprotein (AFP) and ferritin by ELISA, then mice were sacrificed and subjected to histopathological examination of their livers. These were repeated every week till the end of the experiment. The results of the histopathological examination clarified the role of S. mansoni in enhancing and aggravating the carcinogenic effect of DEN; dysplastic changes appeared earlier, with a higher grade and with a smaller dose of DEN in Group II compared to Group I. Serum levels of tumor markers showed earlier statistically significant differences in Group II than in Group I when compared to Group IV. We conclude that S. mansoni accelerates hepatic dysplastic changes in the presence of other risk factors making cancer appear early and with a more aggressive nature, compared to the same risk in absence of schistosomiasis. © 2013 Elsevier B.V.
Authors & Co-Authors
El-Tonsy, Manar Mahmoud
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Hussein, Hesham Mohammed
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Helal, Thanaa El A.
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Tawfik, Rania Ayman
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Koriem, Khaled Mohamed Mohamed
Egypt, Giza
National Research Centre
Hussein, Hend Mohamed
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Statistics
Citations: 33
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1016/j.actatropica.2013.07.024
ISSN:
0001706X
e-ISSN:
18736254
Research Areas
Cancer
Infectious Diseases
Study Design
Cohort Study
Study Approach
Quantitative
Study Locations
Egypt