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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Association study of genes controlling IL-12-dependent IFN-γ immunity: STAT4 alleles increase risk of pulmonary tuberculosis in morocco
Journal of Infectious Diseases, Volume 210, No. 4, Year 2014
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Description
Background. Only a minority of individuals infected with Mycobacterium tuberculosis develop clinical tuberculosis. Genetic epidemiological evidence suggests that pulmonary tuberculosis has a strong human genetic component. Previous genetic findings in Mendelian predisposition to more severe mycobacterial infections, including by M. tuberculosis, underlined the importance of the interleukin 12 (IL-12)/interferon γ (IFN-γ) circuit in antimycobacterial immunity. Methods. We conducted an association study in Morocco between pulmonary tuberculosis and a panel of single-nucleotide polymorphisms (SNPs) covering 14 core IL-12/IFN-γ circuit genes. The analyses were performed in a discovery family-based sample followed by replication in a case-control population. Results. Out of 228 SNPs tested in the family-based sample, 6 STAT4 SNPs were associated with pulmonary tuberculosis (P =. 0013-.01). We replicated the same direction of association for 1 cluster of 3 SNPs encompassing the promoter region of STAT4. In the combined sample, the association was stronger among younger subjects (pulmonary tuberculosis onset <25 years) with an odds ratio of developing pulmonary tuberculosis at rs897200 for GG vs AG/AA subjects of 1.47 (1.06-2.04). Previous functional experiments showed that the G allele of rs897200 was associated with lower STAT4 expression. Conclusions. Our present findings in a Moroccan population support an association of pulmonary tuberculosis with STAT4 promoter-region polymorphisms that may impact STAT4 expression. © 2014 The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4111910/bin/supp_210_4_611__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC4111910/bin/supp_jiu140_jiu140supp.docx
Authors & Co-Authors
Sabri, Ayoub
Morocco, Agdal Rabat
Military Hospital Mohammed V
Morocco, Kenitra
Université Ibn Tofail
Grant, Audrey Virginia
France, Paris
L'institut Des Maladies Génétiques Imagine
France, Paris
Université Paris Cité
Cosker, Kristel
France, Paris
L'institut Des Maladies Génétiques Imagine
France, Paris
Université Paris Cité
El Azbaoui, Safa
Morocco, Agdal Rabat
Military Hospital Mohammed V
Morocco, Kenitra
Université Ibn Tofail
Abid, Ahmed
Morocco, Agdal Rabat
Military Hospital Mohammed V
Abderrahmani-Rhorfi, Ismail
Morocco, Agdal Rabat
Military Hospital Mohammed V
Souhi, Hicham
Morocco, Agdal Rabat
Military Hospital Mohammed V
Janah, Hicham
Morocco, Agdal Rabat
Military Hospital Mohammed V
Alaoui-Tahiri, Kebir
Morocco, Agdal Rabat
Military Hospital Mohammed V
Gharbaoui, Yasser
Morocco, Agdal Rabat
Military Hospital Mohammed V
Benkirane, Majid
Morocco, Agdal Rabat
Military Hospital Mohammed V
Orlova, Marianna O.
Canada, Montreal
L'institut de Recherche du Centre Universitaire de Santé Mcgill
Boland, Anne
France, Evry
Centre National de Recherche en Génomique Humaine
Deswarte, Caroline
France, Paris
L'institut Des Maladies Génétiques Imagine
France, Paris
Université Paris Cité
Migaud, Mélanie
France, Paris
L'institut Des Maladies Génétiques Imagine
France, Paris
Université Paris Cité
Bustamante, Jacinta Cecilia
France, Paris
L'institut Des Maladies Génétiques Imagine
France, Paris
Université Paris Cité
France, Paris
Hôpital Necker Enfants Malades
Schurr, Erwin
Canada, Montreal
L'institut de Recherche du Centre Universitaire de Santé Mcgill
Boisson-Dupuis, Stéphanie
France, Paris
L'institut Des Maladies Génétiques Imagine
France, Paris
Université Paris Cité
United States, New York
Rockefeller University
Casanova, Jean Laurent
France, Paris
L'institut Des Maladies Génétiques Imagine
France, Paris
Université Paris Cité
United States, New York
Rockefeller University
France, Paris
Hôpital Necker Enfants Malades
Abel, Laurent
France, Paris
L'institut Des Maladies Génétiques Imagine
France, Paris
Université Paris Cité
United States, New York
Rockefeller University
El-Baghdadi, Jamila
Morocco, Agdal Rabat
Military Hospital Mohammed V
Statistics
Citations: 34
Authors: 21
Affiliations: 8
Identifiers
Doi:
10.1093/infdis/jiu140
ISSN:
00221899
e-ISSN:
15376613
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study
Case-Control Study
Study Locations
Morocco