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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Effect of standard tuberculosis treatment on plasma cytokine levels in patients with active pulmonary tuberculosis
PLoS ONE, Volume 7, No. 5, Article e36886, Year 2012
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Description
Background: Sputum Mycobacterium tuberculosis (Mtb) culture is commonly used to assess response to antibiotic treatment in individuals with pulmonary tuberculosis (TB). Such techniques are constrained by the slow growth rate of Mtb, and more sensitive methods to monitor Mtb clearance are needed. The goal of this study was to evaluate changes in plasma cytokines in patients undergoing treatment for TB as a means of identifying candidate host markers associated with microbiologic response to therapy. Methods: Twenty-four plasma cytokines/chemokines were measured in 42 individuals diagnosed with active pulmonary TB, 52% were HIV co-infected. Individuals, undergoing a 26-week standard TB treatment, were followed longitudinally over 18 months and measurements were associated with HIV status and rates of sputum culture conversion. Results: Plasma concentrations of interferon-inducible protein-10 (IP-10) and vascular endothelial growth factor (VEGF) were significantly reduced upon TB treatment, regardless of HIV status. By the end of treatment, IP-10 concentrations were significantly lower in HIV negative individuals when compared to HIV-positive individuals (p = 0.02). Moreover, in HIV negative patients, plasma VEGF concentrations, measured as early as 2-weeks post TB treatment initiation, positively correlated with the time of sputum conversion (p = 0.0017). No significant changes were observed in other studied immune mediators. Conclusions: These data suggest that VEGF plasma concentration, measured during early TB treatment, could represent a surrogate marker to monitor sputum culture conversion in HIV uninfected individuals. © 2012 Riou et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3351475/bin/pone.0036886.s001.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC3351475/bin/pone.0036886.s002.tif
Authors & Co-Authors
Riou, Catherine
South Africa, Cape Town
University of Cape Town
Perez Peixoto, Blas
United States, Newark
Rutgers Biomedical and Health Sciences
Masson, Lindi
South Africa, Cape Town
University of Cape Town
Ronacher, Katharina
South Africa, Stellenbosch
Stellenbosch University
Walzl, Gerhard
South Africa, Stellenbosch
Stellenbosch University
Manca, Claudia
United States, Newark
Rutgers Biomedical and Health Sciences
Rustomjee, Roxana
South Africa, Tygerberg
South African Medical Research Council
Mthiyane, Thuli C.P.
South Africa, Tygerberg
South African Medical Research Council
Fallows, Dorothy A.
United States, Newark
Rutgers Biomedical and Health Sciences
Gray, Clive M.
South Africa, Cape Town
University of Cape Town
Kaplan, Gilla
United States, Newark
Rutgers Biomedical and Health Sciences
Statistics
Citations: 90
Authors: 11
Affiliations: 4
Identifiers
Doi:
10.1371/journal.pone.0036886
e-ISSN:
19326203
Research Areas
Infectious Diseases