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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Attitudes of young patients with breast cancer toward fertility loss related to adjuvant systemic therapies. EORTC study 10002 BIG 3-98
Psycho-Oncology, Volume 23, No. 2, Year 2014
Notification
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Description
Objective Infertility due to anticancer treatments is a major source of distress for young patients with cancer. A survey was performed among breast cancer patients younger than 35 years, to evaluate the acceptance of chemotherapy in the context of infertility risk. Methods After obtaining written informed consent, we asked 400 premenopausal, early stage breast cancer patients aged ≤35 years to complete a short, previously pilot-tested questionnaire. Three hundred and eighty-nine patients were evaluable. The association between the explanatory variables and the outcome variables was assessed using logistic regression. Results Two hundred and twenty-eight (59%) participants wanted to have (more) children in the future, whereas 158 (41%) did not. Fifty-seven (36%) of the latter did not want additional children because of fear of cancer recurrence. Thirty-two women (8%) stated they would not accept chemotherapy should it reduce their fertility. This was dependent upon already having children, the wish to have (further) children, geographical area, disease stage, and already planned chemotherapy. One hundred and seventy-one women who would agree to chemotherapy (48%) would accept a risk of infertility of 76-100%. This acceptance was dependent on already having children and the wish to have (more) children. Of the 355 participants (91%) accepting chemotherapy, 48 would accept it only for ≥20% gain in cure. Conclusion For the majority of young patients with breast cancer, cure remains their first priority; for this, they are willing to accept a considerable decrease in future fertility, and only less than 10% will forego chances of cure to preserve fertility. Copyright © 2013 John Wiley & Sons, Ltd.
Authors & Co-Authors
Senkus, Elzbieta
Poland, Gdansk
Gdanski Uniwersytet Medyczny
Gomez, Henry L.
Peru, Lima
Instituto Nacional de Enfermedades Neoplasicas
Dirix, Luc Yves
Belgium, Wilrijk
Sint-augustinus
Jerusalem, Guy
France, Bagnolet
Saft
Murray, Elizabeth M.
South Africa, Observatory
Groote Schuur Hospital
Van Tienhoven, G.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Westenberg, A. Helen
Netherlands, Arnhem
Institute for Radiation Oncology Arnhem
Bottomley, Andrew
Belgium, Brussels
European Organisation for Research and Treatment of Cancer
Rapion, Jérôme
Belgium, Brussels
European Organisation for Research and Treatment of Cancer
Bogaerts, Jan
Belgium, Brussels
European Organisation for Research and Treatment of Cancer
Di Leo, Angelo
Italy, Prato
Hospital of Prato
Neškovic̈-Konstantinovic̈, Zora
Serbia, Belgrade
Institute of Oncology and Radiology of Serbia
Statistics
Citations: 70
Authors: 12
Affiliations: 10
Identifiers
Doi:
10.1002/pon.3384
ISSN:
10579249
e-ISSN:
10991611
Research Areas
Cancer
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Study Approach
Quantitative
Participants Gender
Female