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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effectiveness of a project to prevent HIV vertical transmission in the Republic of Congo
Journal of Antimicrobial Chemotherapy, Volume 68, No. 8, Article dkt102, Year 2013
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Description
To evaluate the effectiveness of a prevention programme against the vertical transmission of HIV in a resource-limited setting and to investigate variables associated with compliance. The Kento-Mwana project (2005-2008) provided counselling, serological and biomole-cular testing and prophylaxis/therapy to HIV-positive pregnant women and their children attending four antenatal clinics in Pointe Noire, Republic of Congo. Expected and actual rates of vertical transmission of HIV were compared. Univariate and multivariate analyses were performed in order to identify variables associated with non-compliance. The observed transmission rate in the group who completed follow-up was 5/290 (1.7%, 95% CI 0.6%-4.1%). The overall estimated transmission rate in the target population, computed taking into account the expected vertical transmission of HIV among drop-outs, was 67-115/638 (10.5%-18.0%). A comparison between this rate and the expected transmission rate in the absence of intervention (25%-40%) showed that the programme was able to prevent approximately 50% of vertical transmissions. Older age (OR 0.33, 95% CI 0.16-0.66, P 1/4 0.002), telephone availability (OR 0.42, 95% CI 0.24-0.72, P 1/4 0.002) and occupation (OR 0.57, 95% CI 0.29-1.10, P 1/4 0.092) were associated with better compliance. Despite the vast majority of women accepting counselling and testing, many of them refused prophylaxis or dropped out, thus reducing the effectiveness of the intervention from an ideal 2% to a still important but less impressive median transmission rate of 15% (range 10.5%-18%). Promoting participation and compliance, rather than increasing the potency of antiretroviral regimens, is crucial for preventing the vertical transmission of HIV in Africa. © The Author 2013. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.
Authors & Co-Authors
Bisio, Francesca
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Masini, Giulia
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Vacca, Elisabetta Blasi
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Calzi, Anna
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Cardinale, Francesco
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Bruzzone, Bianca Marisa
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Bruzzi, Paolo A.
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Viscoli, Claudio
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Kento-Mwana, K.
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Nkouendolo, Jean Pierre
Congo
Departmental Unit Against Aids
Moutou, Joseph
Congo
Departmental Direction of the Ministry of Health
Banguissa, Hubert
Congo
Tié-tié Hospital
Nicolini, Laura Ambra
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Schenone, Eva
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Repetto, Ernestina
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Montaldo, Chiara
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Ferrando, Sara
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Righi, Elda
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Dentone, Chiara
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Farinella, Sara Tita
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Vitale, Francesco M.
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Izzo, Manuela
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Mularoni, Alessandra
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Mikulska, Małgorzata Karolina
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Di Stefano, Letizia
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Malfatto, Emanuele Nadir
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Bernardini, Claudia
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Ginocchio, Francesca
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Secondo, Giovanni
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Delfino, Emanuele
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Nicco, Elena
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Prinapori, Roberta
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Parisini, Andrea
Italy, Genoa
Irccs San Martino Polyclinic Hospital
de Hoffer, Laura
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Mesini, Alessio
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Grignolo, Sara
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Taramasso, Lucia
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Giacobbe, Daniele Roberto
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Artom, Francesco
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Dini, Simone
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Beltrame, Andrea
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Ratto, Sandra
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Mbongou, Franc Astyanax Mayinda
Congo, Brazzaville
Army Hospital
Miguel, Landry M.
Congo, Brazzaville
Army Hospital
Nzagou, Abdon C.
Congo, Brazzaville
Army Hospital
Mayembo, Patrice
Congo, Brazzaville
Army Hospital
Ibata, Daniel
Congo, Brazzaville
Army Hospital
Ventura, Agostina
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Nigro, Nicola
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Andrei, Cristina
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Icardi, Giancarlo
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Statistics
Citations: 51
Authors: 51
Affiliations: 5
Identifiers
Doi:
10.1093/jac/dkt102
ISSN:
03057453
e-ISSN:
14602091
Research Areas
Cancer
Infectious Diseases
Maternal And Child Health
Study Design
Randomised Control Trial
Cross Sectional Study
Cohort Study
Study Locations
Congo
Participants Gender
Female