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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Placental inflammation and perinatal outcome
European Journal of Obstetrics and Gynecology and Reproductive Biology, Volume 108, No. 2, Year 2003
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Description
Objective: To examine the role of placental inflammation in adverse obstetrical outcome (AOO). Methods: Analysis of perinatal data of 701 randomly selected mothers of singleton infants, Mombasa, Kenya. Results: There were 661 (94.3%) live infants and 40 (5.7%) stillbirths. Out of the live born infants, 78 (12.4%) had a low birth weight (LBW < 2500g); 33 of them were preterm and 41 small for gestational age (SGA). The incidence of neonatal sepsis and post partum endometritis was 3.6 and 19.8%, respectively. The perinatal death rate was estimated to be 7.3% (51/701). The prevalence of acute placental inflammation was 19.6%. Acute placental inflammation was independently associated with preterm low birth weight (ARR=3.8, 95% CI=1.7-8.9, P<0.01), stillbirth (ARR=2.3, 95% CI=1.1-5.0, P=0.03) and perinatal death (ARR=2.8, 95% CI=1.4-5.4, P<0.01). Women with acute placental inflammation had a two-fold higher risk for AOO (32.6 versus 15.2%, respectively, ARR=2.5, 95% CI=1.3-4.8, P<0.01). Other risk factors for AOO were bad obstetrical history, low haemoglobin level and leucocytosis. Conclusions: The incidence of adverse obstetrical outcome defined as low birth weight, low Apgar score, perinatal mortality and post partum endometritis, was high in this population. Acute placental inflammation was associated with preterm birth, stillbirth and perinatal death. More research is needed to study the role of infection in adverse obstetrical outcome, and to design interventions to decrease infectious morbidity and mortality in pregnancy. © 2002 Elsevier Science Ireland Ltd. All rights reserved.
Authors & Co-Authors
Mwanyumba, Fabian
Kenya, Mombasa
Coast Provincial General Hospital, Kenya
Belgium, Ghent
Universiteit Gent
Inion, Ingrid
Belgium, Ghent
Universiteit Gent
Gaillard, Philippe
Switzerland, Geneva
Organisation Mondiale de la Santé
Mandaliya, Kishor N.
Kenya, Mombasa
Coast Provincial General Hospital, Kenya
Praet, Marleen M.
Belgium, Ghent
Universiteit Gent
Temmerman, Marleen I.L.
Belgium, Ghent
Universiteit Gent
Statistics
Citations: 22
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1016/S0301-2115(02)00438-4
ISSN:
03012115
Research Areas
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Kenya
Participants Gender
Female