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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
The epidemiology of visceral leishmaniasis and asymptomatic leishmanial infection in a highly endemic Bangladeshi village
American Journal of Tropical Medicine and Hygiene, Volume 76, No. 5, Year 2007
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Description
We examined the epidemiology of kala-azar and asymptomatic leishmanial infection measured by serologic and leishmanin skin test results in a Bangladeshi community. In a subset, we measured serum retinol, zinc and C-reactive protein (CRP). Kala-azar and seroconversion incidence were 15.6 and 63.1 per 1,000 person-years, respectively. Proximity to a previous kala-azar case increased the likelihood of both kala-azar and asymptomatic infection. Bed net use protected against kala-azar (rate ratio = 0.35, P < 0.01), but not subclinical infection (rate ratio = 1.1, P = 0.82). Kala-azar patients were younger (P < 0.001) and reported lower red meat consumption (P < 0.01) than asymptomatic seropositive individuals. Retinol and zinc levels were lower in current kala-azar patients and those who later developed kala-azar compared with uninfected and asymptomatically infected subjects. The CRP levels were higher in kala-azar patients compared with the other two groups. Low red meat intake and poor zinc and retinol status may characterize a group at higher risk of symptomatic disease. Copyright © 2007 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Bern, Caryn
United States, Atlanta
Coordinating Center for Infectious Diseases
Haque, Rashidul
Bangladesh, Dhaka
Icddr, b Centre for Health and Population Research
Chowdhury, Rajib Nayan
Bangladesh, Dhaka
Icddr, b Centre for Health and Population Research
Ali, Mustakim
Bangladesh, Dhaka
Icddr, b Centre for Health and Population Research
Kurkjian, Katie M.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Vaz, Louise Elaine
United States, Nashville
Vanderbilt University School of Medicine
Amann, Josef
United States, Atlanta
Centers for Disease Control and Prevention
Wahed, Mohammad Abdul
Bangladesh, Dhaka
Icddr, b Centre for Health and Population Research
Wagatsuma, Yukiko
Japan, Tsukuba
University of Tsukuba
Breiman, Robert F.
Kenya, Kisumu
Centers for Disease Control and Prevention, Kenya
Williamson, John Michael
United States, Atlanta
Coordinating Center for Infectious Diseases
Secor, William Evan
United States, Atlanta
Coordinating Center for Infectious Diseases
Maguire, James H.
United States, Baltimore
University of Maryland School of Medicine
Statistics
Citations: 121
Authors: 13
Affiliations: 8
Identifiers
Doi:
10.4269/ajtmh.2007.76.909
ISSN:
00029637
Research Areas
Health System And Policy
Study Design
Cohort Study