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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Prevalence of pfmdr1, pfcrt, pfdhfr and pfdhps mutations associated with drug resistance, in Luanda, Angola
Malaria Journal, Volume 7, Article 236, Year 2008
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Description
Background. Malaria is the infectious disease causing the highest morbidity and mortality in Angola and due to widespread chloroquine (CQ) resistance, the country has recently changed its first-line treatment recommendations for uncomplicated malaria, from CQ to artemisinin combination therapies (ACT) in adults, and sulphadoxine/pyrimethamine (S/P) in pregnant women. Loss of SP sensitivity is, however, progressing rapidly in Africa and, in this study, were investigated a number of molecular markers associated to CQ and S/P. Methods. Blood samples were collected from 245 children with uncomplicated malaria, admitted at the Pediatric Hospital Dr. David Bernardino (HPDB), Angola, and the occurrence of mutations in Plasmodium falciparum was investigated in the pfmdr1 (N86Y) and pfcrt (K76T) genes, associated with CQ resistance, as well as in pfdhfr (C59R) and pfdhps (K540E), conferring SP resistance. Results. The frequencies of pfmdr1 mutations in codon 86 were 28.6% N, 61.3% Y and 10.1% mixed infections (NY). The frequency of pfcrt mutations in codon 76 were 93.9% K, 5.7% T and 0.4% mixed infections (KT). For pfdhfr the results were in codon 59, 60.6% C, 20.6% R and 18.8% mixed infections (CR). Concerning pfdhps, 6.3% of the isolates were bearers of the mutation 540E and 5.4% mixed infections (K540E). Conclusion. The results of this epidemiologic study showed high presence of CQ resistance markers while for SP a much lower prevalence was detected for the markers under study. © 2008 Figueiredo et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Figueiredo, Paula
Portugal, Lisbon
Universidade Nova de Lisboa
Benchimol, Carla
Angola, Luanda
Hospital Pediátrico David Bernardino
Lopes, Dinora
Portugal, Lisbon
Universidade Nova de Lisboa
Bernardino, Luís
Angola, Luanda
Hospital Pediátrico David Bernardino
do Rosário, Virgílio Estólio
Portugal, Lisbon
Universidade Nova de Lisboa
Varandas, Luís
Portugal, Lisbon
Universidade Nova de Lisboa
Nogueira, Fátima
Portugal, Lisbon
Universidade Nova de Lisboa
Statistics
Citations: 43
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.1186/1475-2875-7-236
e-ISSN:
14752875
Research Areas
Cancer
Genetics And Genomics
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Study Locations
Angola
Participants Gender
Female