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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The effect of treatment of vaginal infections on shedding of human immunodeficiency virus type 1
Journal of Infectious Diseases, Volume 183, No. 7, Year 2001
Notification
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Description
To assess the effect of treatment of vaginal infections on vaginal shedding of cell-free human immunodeficiency virus type 1 (HIV-1) and HIV-1-infected cells, HIV-1-seropositive women were examined before and after treatment of Candida vulvovaginitis, Trichomonas vaginitis, and bacterial vaginosis. For Candida (n = 98), vaginal HIV-1 RNA decreased from 3.36 to 2.86 log10copies/swab (P < .001), as did the prevalence of HIV-1 DNA (36% to 17%; odds ratio [OR], 2.8; 95% confidence interval [CI], 1.3-6.5). For Trichomonas vaginitis (n = 55), HIV-1 RNA decreased from 3.67 to 3.05 log10copies/swab (P < .001), but the prevalence of HIV-1 DNA remained unchanged (22%-25%; OR, 0.8; 95% CI, 0.3-2.2). For bacterial vaginosis (n = 73), neither the shedding of HIV-1 RNA (from 3.11 to 2.90 log10copies/swab; P = .14) nor the prevalence of DNA (from 21% to 23%; OR, 0.8; 95% CI, 0.3-2.0) changed. Vaginal HIV-1 decreased 3.2- and 4.2-fold after treating Candida and Trichomonas, respectively. These data suggest that HIV-1 transmission intervention strategies that incorporate diagnosis and treatment of these prevalent infections warrant evaluation. © 2001 Infectious Diseases Society of America.
Authors & Co-Authors
Wang, Chia C.
United States, Seattle
University of Washington
McClelland, Raymond Scott
United States, Seattle
University of Washington
Ireland, Cork
University College Cork
Overbaugh, Julie M.
United States, Seattle
Fred Hutchinson Cancer Research Center
Emery, Sandra R.
United States, Seattle
Fred Hutchinson Cancer Research Center
Mandaliya, Kishor N.
Kenya, Mombasa
Coast Provincial General Hospital, Kenya
Chohan, Bhavna H.
Kenya, Mombasa
Coast Provincial General Hospital, Kenya
Ndinya-Achola, Jeckoniah O.
Kenya, Nairobi
University of Nairobi
Bwayo, Job J.
Kenya, Nairobi
University of Nairobi
Kreiss, Joan K.
United States, Seattle
University of Washington
Statistics
Citations: 226
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1086/319287
ISSN:
00221899
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Randomised Control Trial
Cross Sectional Study
Case-Control Study
Participants Gender
Female