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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Multiple HIV-1 infections with evidence of recombination in heterosexual partnerships in a low risk Rural Clinical Cohort in Uganda
Virology, Volume 411, No. 1, Year 2011
Notification
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Description
We report on the frequency of multiple infections, generation of recombinants and consequences on disease progression in 35 HIV-1 infected individuals from 7 monogamous and 6 polygamous partnerships within a Rural Clinical Cohort in Uganda. The env-C2V3, gag-p24 and pol-IN genes were sequenced. Single genome amplified half genome sequences were used to map recombination breakpoints. Three participants were dually infected with subtypes A and D, one case with subtype A and A/D recombinant and the fifth with 2 phylogenetically distinct A/D recombinants. Occurrence of A/D recombination was observed in two multiple infected individuals. Rate of late stage WHO events using Cox regression was 3 times greater amongst multiple infected compared to singly infected individuals (hazard ratio 3.35; 95% CI 1.09, 10.3; p=0.049). We have shown that polygamous relationships involving subtype discordant partnerships was a major contributor of multiple infections with generation of inter subtype recombinants in our cohort. © 2010 Elsevier Inc.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3041926/bin/mmc1.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3041926/bin/mmc2.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3041926/bin/mmc3.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3041926/bin/mmc4.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3041926/bin/mmc5.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3041926/bin/mmc6.doc
Authors & Co-Authors
Ssemwanga, Deogratius
Unknown Affiliation
Lyagoba, Fred F.
Unknown Affiliation
Ndembi, Nicaise N.
Unknown Affiliation
Mayanja, Billy Nsubuga
Unknown Affiliation
Larke, Natasha L.
Unknown Affiliation
Wang, Shuyi
Unknown Affiliation
Baalwa, Joshua
Unknown Affiliation
Williamson, Carolyn
Unknown Affiliation
Grosskurth, Heiner
Unknown Affiliation
Kaleebu, Pontiano P.
Unknown Affiliation
Statistics
Citations: 32
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1016/j.virol.2010.12.025
ISSN:
00426822
e-ISSN:
10960341
Research Areas
Environmental
Infectious Diseases
Study Design
Cohort Study
Study Locations
Uganda