Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Goitrous endemic in Guinea
The Lancet, Volume 344, No. 8938, Year 1994
Notification
URL copied to clipboard!
Description
Summary. We identified a major goitrous area in the Republic of Guinea, characterised by an overall goitre prevalence of 70% in adults. Thyroid swelling was sometimes present at birth and affected 55% of schoolchildren. A difference between sexes appeared at puberty. Endemic cretinism, mainly in its myxoedematous form, was found in about 2% of goitrous patients. In this region, iodine deficiency is the primary causative factor (median urinary concentrations of 16 μg/L, and in 69% of inhabitants below the critical threshold of 20 μg/L). The diet contained substantial amounts of thiocyanate anions (median 6 mg/L in urine and in 27%, more than 10 mg/L) likely to further depress iodine bioavailability. Other dietary compounds, notably flavonoids were suspected to contribute. Overall nutritional and general health appeared satisfactory. The affected population is borderline euthyroid with a trend towards hypothyroidism in protracted disease. This area of Guinea may be regarded as the epicentre of the west African endemic and as one of the most severely goitrous regions ever described, requiring urgent public health measures. © 1994.
Authors & Co-Authors
Kondé, Mandy Kader
Guinea
Direction of Public Health
Daffe, M.
Guinea
Direction of Public Health
Sylla, B.
Guinea
Direction of Public Health
Barry, O.
Guinea
Direction of Public Health
Diallo, S.
Guinea
Direction of Public Health
Ingenbleek, Yves
France, Strasbourg
Université de Strasbourg
Statistics
Citations: 35
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1016/S0140-6736(94)90461-8
ISSN:
01406736
Study Design
Cross Sectional Study
Study Locations
Guinea