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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Plasmodium falciparum genotype population dynamics in asymptomatic children from Senegal
Microbes and Infection, Volume 8, No. 7, Year 2006
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Description
In areas where malaria is endemic, infected individuals generally harbor a mixture of genetically distinct Plasmodium falciparum parasite populations. For the first time, we studied temporal variations of blood parasite densities and circulating genotypes in asymptomatic Senegalese children, at time intervals as short as 4-12 h. Twenty-one Senegalese children, presenting with an asymptomatic P. falciparum infection, were sampled eight times within three days. Parasite density was assessed by thick blood smears, and all infecting genotypes were quantified by the fragment-analysis method. Parasite densities showed dramatic fluctuations up to a 1 to 1000 ratio, with at least one peak of parasite density. Polyclonal infections were detected in all children, with a multiplicity of infection of 5.2-6.8 genotypes per child. A single sample never reflected the full complexity of the parasite populations hosted by a given individual. Genotypes with different behaviors were detected in all children, some genotypes undergoing major fluctuations, while others were highly stable during the follow-up. A single peripheral blood sampling does not reflect the total parasite load. Repeated sampling is needed to have a more detailed scheme of parasite population dynamics and a better knowledge of the true complexity of an infection. © 2006 Elsevier SAS. All rights reserved.
Authors & Co-Authors
Jafari-Guemouri, Sayeh
France, Marseille
Ird Institut de Recherche Pour le Developpement
Boudin, Christian
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Fievét, Nadine
France, Marseille
Ird Institut de Recherche Pour le Developpement
Ndiaye, Pape
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Deloron, Philippe
France, Marseille
Ird Institut de Recherche Pour le Developpement
Statistics
Citations: 34
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1016/j.micinf.2006.01.023
ISSN:
12864579
e-ISSN:
1769714X
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Senegal