Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
High Rates of Uncontrolled Blood Pressure in Malawian Adults Living with HIV and Hypertension
Global Heart, Volume 16, No. 1, Article 81, Year 2021
Notification
URL copied to clipboard!
Description
Background: Hypertension is among the most commonly diagnosed non-communicable diseases in Africa, and studies have demonstrated a high prevalence of hypertension among individuals with HIV. Despite high prevalence, there has been limited attention on the clinical outcomes of hypertension treatment in this population. Objective: We sought to characterize rates of and factors associated with blood pressure control over one year among individuals on antiretroviral therapy (ART) and antihypertensive medications. Methods: We performed a prospective observational cohort study at an HIV clinic in Malawi. We defined uncontrolled hypertension as a systolic blood pressure ≥140 mm Hg and/or diastolic blood pressure ≥90 mm Hg at two or more follow-up visits during the year, while controlled hypertension was defined as <140 mm Hg systolic and <90 mm Hg diastolic at all visits, or at all but one visit. We calculated an antihypertensive non-adherence score based on self-report of missed doses at each visit (higher score = worse adherence) and used rank sum and chi-square tests to compare sociodemographic and clinical factors (including adherence) associated with blood pressure control over the year. Results: At study entry, 158 participants (23.5%) were on antihypertensive medication; participants had a median age of 51.0 years, were 66.5% female, and had a median of 6.9 years on ART. 19.0% (n = 30) achieved blood pressure control over the year of follow-up. Self-reported non-adherence to hypertension medications was the only factor significantly associated with uncontrolled blood pressure. The average non-adherence score for those with controlled blood pressure was 0.22, and for those with uncontrolled blood pressure was 0.61 (p = 0.009). Conclusions: Adults living with HIV and hypertension in our cohort had low rates of blood pressure control over one year associated with self-reported non-adherence to antihypertensive medications. Given the high prevalence and incidence of hypertension, interventions to improve blood pressure control are needed to prevent associated long-term cardio- and cerebrovascular morbidity and mortality. © 2021 Elsevier B.V.. All rights reserved.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC8663744/bin/gh-16-1-1081-s1.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC8663744/bin/gh-16-1-1081-s2.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC8663744/bin/gh-16-1-1081-s3.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC8663744/bin/gh-16-1-1081-s4.pdf
Authors & Co-Authors
Hoffman, Risa M.
United States, Los Angeles
University of California, Los Angeles
Chibwana, Florence
Unknown Affiliation
Kahn, Daniel G.
United States, Los Angeles
University of California, Los Angeles
Banda, Ben Allan
Unknown Affiliation
Phiri, Linna
Unknown Affiliation
Chimombo, Mayamiko
Unknown Affiliation
Kussen, Chiulemu
Unknown Affiliation
Sigauke, Hitler
Unknown Affiliation
Moses, Agnes
Unknown Affiliation
van Oosterhout, Joep J.G.
Unknown Affiliation
Phiri, Sam John Peter
Unknown Affiliation
Currier, Judith Silverstein
United States, Los Angeles
University of California, Los Angeles
Moucheraud, Corrina
United States, Los Angeles
University of California, Los Angeles
Statistics
Citations: 4
Authors: 13
Affiliations: 1
Identifiers
Doi:
10.5334/gh.1081
ISSN:
22118160
Research Areas
Health System And Policy
Infectious Diseases
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Malawi
Participants Gender
Female