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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci
eLife, Volume 10, Article e67113, Year 2021
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Description
Multidrug-resistant Streptococcus pneumoniae emerge through the modification of core genome loci by interspecies homologous recombinations, and acquisition of gene cassettes. Both occurred in the otherwise contrasting histories of the antibiotic-resistant S. pneumoniae lineages PMEN3 and PMEN9. A single PMEN3 clade spread globally, evading vaccine-induced immunity through frequent serotype switching, whereas locally circulating PMEN9 clades independently gained resistance. Both lineages repeatedly integrated Tn916-type and Tn1207.1- type elements, conferring tetracycline and macrolide resistance, respectively, through homologous recombination importing sequences originating in other species. A species-wide dataset found over 100 instances of such interspecific acquisitions of resistance cassettes and flanking homologous arms. Phylodynamic analysis of the most commonly sampled Tn1207.1-type insertion in PMEN9, originating from a commensal and disrupting a competence gene, suggested its expansion across Germany was driven by a high ratio of macrolide-to-b-lactam consumption. Hence, selection from antibiotic consumption was sufficient for these atypically large recombinations to overcome species boundaries across the pneumococcal chromosome. © 2021, eLife Sciences Publications Ltd. All rights reserved.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC8321556/bin/elife-67113-fig1-data1.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC8321556/bin/elife-67113-fig9-data1.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC8321556/bin/elife-67113-transrepform.docx
Authors & Co-Authors
van der Linden, Mark P.G.
Germany, Aachen
Uniklinik Rwth Aachen
McGee, Lesley
United States, Atlanta
Centers for Disease Control and Prevention
de Lencastre, Hermínia M.
Portugal, Lisbon
Universidade Nova de Lisboa
United States, New York
Rockefeller University
Turner, Paul D.
Cambodia, Siem Reap
Angkor Hospital for Children
United Kingdom, Oxford
University of Oxford
Song, Jae-hoon
South Korea, Suwon
Skku School of Medicine
Lo, Stephanie W.
United Kingdom, Hinxton
Wellcome Sanger Institute
Gladstone, Rebecca A.
United Kingdom, Hinxton
Wellcome Sanger Institute
Sa-Leao, R.
Portugal, Lisbon
Universidade Nova de Lisboa
Ko, Kwan Soo
South Korea, Suwon
Skku School of Medicine
Hanage, William Paul
United States, Boston
Harvard T.h. Chan School of Public Health
Breiman, Robert F.
United States, Atlanta
Emory University
Beall, Bernard W.
United States, Atlanta
Centers for Disease Control and Prevention
Bentley, Stephen D.
United Kingdom, Hinxton
Wellcome Sanger Institute
Croucher, Nicholas J.
United Kingdom, London
Medical Research Council
Statistics
Citations: 12
Authors: 14
Affiliations: 11
Identifiers
Doi:
10.7554/eLife.67113
ISSN:
2050084X
Research Areas
Genetics And Genomics