Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
engineering
New model of subconjunctival tumor development in rabbits
Journal of Biomedical Optics, Volume 18, No. 7, Article 070501, Year 2013
Notification
URL copied to clipboard!
Description
Conjunctival squamous cell carcinoma (SCC) is an uncommon disease. However, SCC has recently become an important clinical problem due the identification of a significantly high incidence of SCC among a group of black African patients with AIDS. However, basic research concerning SCC, including both intraepithelial and invasive squamous neoplasia, is limited due to the lack of an ocular tumor animal model. Specifically, current ocular imaging and treatment modalities are insufficient for investigating currently available small animal models, because the conjunctival space is not comparable to that of humans. We describe the development of a reproducible model of subconjunctival squamous carcinoma in moderate-sized immunocompetent rabbits. Under optical coherence tomography guidance, 1 × 107 VX2 carcinoma cells are inoculated into the subconjunctival space of 3 to 4-kg New Zealand white rabbits. Malignant tumor involvement developed on the subconjunctival space after an average of 1 to 2 weeks. This subconjunctival tumor model induction method will likely facilitate a broad range of investigation of subconjunctival cancer diagnostics and therapeutics. © Society of Photo-Optical Instrumentation Engineers.
Authors & Co-Authors
Hwang, Sang Seok
South Korea, Busan
Pukyong National University
Kim, Jeong Eun
South Korea, Busan
Pukyong National University
Chun, Bong Kwon
South Korea, Busan
Kosin University, College of Medicine
Jung, Sangbong
South Korea, Gimhae
Gimhae College
Park, Eun-kee
South Korea, Busan
Kosin University, College of Medicine
South Korea, Busan
Kosin University
Lee, Hu Jang
South Korea, Jinju
Gyeongsang National University
Jung, Mannhong
South Korea, Busan
Kosin University
Lee, Sang Joon
South Korea, Busan
Kosin University
Noh, Gwang Myung
South Korea, Busan
Kosin University
Masanganise, Rangarirai
Zimbabwe, Harare
University of Zimbabwe
Oak, Chulho
South Korea, Busan
Kosin University, College of Medicine
South Korea, Busan
Kosin University
Ahn, Yeh Chan
South Korea, Busan
Pukyong National University
Statistics
Citations: 12
Authors: 12
Affiliations: 6
Identifiers
Doi:
10.1117/1.JBO.18.7.070501
ISSN:
10833668
e-ISSN:
15602281
Research Areas
Cancer
Infectious Diseases
Study Design
Cohort Study