Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases - Part II
Current Medicinal Chemistry, Volume 19, No. 14, Year 2012
Notification
URL copied to clipboard!
Description
Infections with protozoan parasites are a major cause of disease and mortality in many tropical countries of the world. Diseases caused by species of the genera Trypanosoma (Human African Trypanosomiasis and Chagas Disease) and Leishmania (various forms of Leishmaniasis) are among the seventeen "Neglected Tropical Diseases" (NTDs) defined by the WHO. Furthermore, malaria (caused by various Plasmodium species) can be considered a neglected disease in certain countries and with regard to availability and affordability of the antimalarials. Living organisms, especially plants, provide an innumerable number of molecules with potential for the treatment of many serious diseases. The current review attempts to give an overview on the potential of such plant-derived natural products as antiprotozoal leads and/or drugs in the fight against NTDs. In part I, a general description of the diseases, the current state of therapy and need for new therapeuticals, assay methods and strategies applied in the search for new plant derived natural products against these diseases and an overview on natural products of terpenoid origin with antiprotozoal potential were given. The present part II compiles the current knowledge on natural products with antiprotozoal activity that are derived from the shikimate pathway (lignans, coumarins, caffeic acid derivatives), quinones of various structural classes, compounds formed via the polyketide pathways (flavonoids and related compounds, chromenes and related benzopyrans and benzofurans, xanthones, acetogenins from Annonaceae and polyacetylenes) as well as the diverse classes of alkaloids. In total, both parts compile the literature on almost 900 different plant-derived natural products and their activity data, taken from over 800 references. These data, as the result of enormous efforts of numerous research groups world-wide, illustrate that plant secondary metabolites represent an immensely rich source of chemical diversity with an extremely high potential to yield a wealth of lead structures towards new therapies for NTDs. Only a small percentage, however, of the roughly 200,000 plant species on earth have been studied chemically and only a small percentage of these plants or their constituents has been investigated for antiprotozoal activity. The repository of plant-derived natural products hence deserves to be investigated even more intensely than it has been up to present. © 2012 Bentham Science Publishers.
Authors & Co-Authors
Schmidt, Thomas Jürgen
Germany, Munster
University of Münster
Khalid, Sami Ahmed
Sudan, Omdurman
University of Science and Technology
Romanha, Álvaro José
Brazil, Florianopolis
Universidade Federal de Santa Catarina
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Alves, Tânia Maria De Almeida
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Biavatti, Maique Weber
Brazil, Florianopolis
Universidade Federal de Santa Catarina
Brun, Reto
Switzerland, Basel
Universitat Basel
Da Costa, Fernando Batista
Brazil, Sao Paulo
Universidade de São Paulo
De-Castro, Solange Lisboa
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Ferreira, Vítor Francisco
Brazil, Niteroi
Universidade Federal Fluminense
Lacerda, Marcus V. G.
Brazil, Manaus
Fundacao de Medicina Tropical do Amazonas
Lago, J. H.G.
Brazil, Sao Paulo
Universidade Federal de São Paulo
Leon, Leonor Laura Pinto
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Lopes, Norberto Peporine
Brazil, Sao Paulo
Universidade de São Paulo
das Neves Amorim, Rodrigo César
Brazil, Manaus
Instituto Nacional de Pesquisas da Amazonia
Niehues, Michael
Brazil, Sao Paulo
Universidade de São Paulo
Ogungbe, Ifedayo Victor
United States, Huntsville
The University of Alabama in Huntsville
Pohlit, Adrian Martin
Brazil, Manaus
Instituto Nacional de Pesquisas da Amazonia
Scotti, Marcus T.
Brazil, Joao Pessoa
Universidade Federal da Paraíba
Setzer, William N.
United States, Huntsville
The University of Alabama in Huntsville
de Soeiro, Maria Nazaré C.
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Steindel, Mário
Brazil, Florianopolis
Universidade Federal de Santa Catarina
Tempone, Andre Gustavo
Brazil, Cerqueira Cesar
Instituto Adolfo Lutz
Statistics
Citations: 22
Authors: 22
Affiliations: 13
Identifiers
Doi:
10.2174/092986712800229087
ISSN:
09298673
e-ISSN:
1875533X
Research Areas
Infectious Diseases