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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
21-day schedule oral etoposide in children- a feasibility study
European Journal of Cancer, Volume 29, No. 16, Year 1993
Notification
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Description
To determine the feasibility and toxicity of prolonged oral etoposide in children, 22 patients with relapsed or refractory disease were commenced on etoposide 50-100 mgs/m2 per day for 21 days. A second course was administered after full blood count recovery, followed by disease reassessment. In total, 72 courses were evaluable for toxicity, with 10% of completed courses complicated by febrile neutropenia. 15 patients were evaluable for response, with 1 partial response, 10 stable disease and 4 progressive disease. This schedule was well tolerated with acceptable toxicity when doses of less than 80 mg/m2/day were administered and warrants further evaluation. © 1993.
Authors & Co-Authors
Davidson, Alan I.G.
United Kingdom, Sutton
Royal Marsden Hospital
Stevens, Michaël C.G.
United Kingdom, Birmingham
Birmingham Children's Hospital
Pinkerton, Charles Ross
United Kingdom, Sutton
Royal Marsden Hospital
Statistics
Citations: 22
Authors: 3
Affiliations: 4
Identifiers
Doi:
10.1016/0959-8049(93)90210-7
ISSN:
09598049
Research Areas
Health System And Policy
Maternal And Child Health