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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Kaempferol sensitizes colon cancer cells to TRAIL-induced apoptosis
Biochemical and Biophysical Research Communications, Volume 375, No. 1, Year 2008
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Description
Kaempferol is a natural compound contained in edible plants, and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising anti-cancer agent. Here, we show for the first time that the combined treatment with kaempferol and TRAIL drastically induced apoptosis in human colon cancer SW480 cells, compared to single treatments. Kaempferol markedly up-regulated TRAIL receptors, DR5 and DR4. DR5 but not DR4 siRNA efficiently blocked apoptosis induced by the co-treatment with kaempferol and TRAIL, indicating that DR5 up-regulation by kaempferol helps to enhance TRAIL actions. Moreover, we examined the combined effect on normal human cells. The co-treatment induced no apoptosis in normal human peripheral blood mononuclear cells and little apoptosis in normal human hepatocytes. These results suggest that kaempferol is useful for TRAIL-based treatments for cancer. © 2008 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Yoshida, Tatsushi
Japan, Kyoto
Graduate School of Medical Science
Konishi, Masako
Japan, Kyoto
Graduate School of Medical Science
Horinaka, Mano
Japan, Kyoto
Graduate School of Medical Science
Yasuda, Takashi
Japan, Kyoto
Graduate School of Medical Science
Goda, Ahmed E.
Japan, Kyoto
Graduate School of Medical Science
Egypt, Tanta
Faculty of Pharmacy
Taniguchi, Hiroya
Japan, Kyoto
Graduate School of Medical Science
Yano, Kimihiro
Japan, Kyoto
Graduate School of Medical Science
Wakada, Miki
Japan, Kyoto
Graduate School of Medical Science
Sakai, Toshiyuki
Japan, Kyoto
Graduate School of Medical Science
Statistics
Citations: 127
Authors: 9
Affiliations: 2
Identifiers
Doi:
10.1016/j.bbrc.2008.07.131
ISSN:
0006291X
e-ISSN:
10902104
Research Areas
Cancer