Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Incidence and severity of respiratory syncytial virus pneumonia in rural kenyan children identified through hospital surveillance
Clinical Infectious Diseases, Volume 49, No. 9, Year 2009
Notification
URL copied to clipboard!
Description
Background: Although necessary for developing a rationale for vaccination, the burden of severe respiratory syncytial virus (RSV) disease in children in resource-poor settings remains poorly defined. Methods: We conducted prospective surveillance of severe and very severe pneumonia in children aged <5 years admitted from 2002 through 2007 to Kilifi district hospital in coastal Kenya. Nasal specimens were screened for RSV antigen by immunofluorescence. Incidence rates were estimated for the well-defined population. Results: Of 25,149 hospital admissions, 7359 patients (29%) had severe or very severe pneumonia, of whom 6026 (82%) were enrolled. RSV prevalence was 15% (20% among infants) and 27% during epidemics (32% among infants). The proportion of case patients aged ≥3 months was 65%, and the proportion aged ≥6 months was 43%. Average annual hospitalization rates were 293 hospitalizations per 100,000 children aged <5 years (95% confidence interval, 271-371 hospitalizations per 100,000 children aged <5 years) and 1107 hospitalizations per 100,000 infants (95% confidence interval, 1012-1211 hospitalizations per 100,000 infants). Hospital admission rates were double in the region close to the hospital. Few patients with RSV infection had life-threatening clinical features or concurrent serious illnesses, and the associated mortality was 2.2%. Conclusions: In this low-income setting, rates of hospital admission with RSV-associated pneumonia are substantial; they are comparable to estimates from the United States but considerably underestimate the burden in the full community. An effective vaccine for children aged >2 months (outside the age group of poor responders) could prevent a large portion of RSV disease. Severity data suggest that the justification for RSV vaccination will be based on the prevention of morbidity, not mortality. © 2009 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Nokes, David James
Kenya, Kilifi
Centre for Geographic Medicine Research
United Kingdom, Coventry
University of Warwick
Kenya, Kilifi
Kemri-wellcome Trust Collaborative Research Programme
Ngama, Mwanajuma J.
Kenya, Kilifi
Centre for Geographic Medicine Research
Bett, Anne
Kenya, Kilifi
Centre for Geographic Medicine Research
Abwao, John
Kenya, Kilifi
Centre for Geographic Medicine Research
Munywoki, Patrick Kiio
Kenya, Kilifi
Centre for Geographic Medicine Research
English, Michael C.
Kenya, Kilifi
Centre for Geographic Medicine Research
United Kingdom, Oxford
University of Oxford
Scott, John Anthony Gerard
Kenya, Kilifi
Centre for Geographic Medicine Research
United Kingdom, Oxford
Nuffield Department of Medicine
Cane, Patricia A.
United Kingdom, London
Public Health England
Medley, Graham F.
United Kingdom, Coventry
University of Warwick
Statistics
Citations: 145
Authors: 9
Affiliations: 6
Identifiers
Doi:
10.1086/606055
ISSN:
10584838
Research Areas
Health System And Policy
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Kenya