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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Romiplostim in children with chronic refractory ITP: Randomized placebo controlled study
Annals of Hematology, Volume 90, No. 11, Year 2011
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Description
Romiplostim stimulates thrombopoietin receptor to increase platelet production of megakaryocytes in idiopathic thrombocytopenic purpura (ITP). This study aimed to evaluate the safety and efficacy of romiplostim in children with chronic ITP. Eighteen patients with chronic ITP, either none responsive or failed to maintain response on two or more therapeutic modalities, were enrolled. Patients were randomized (2:1) to receive romiplostim or placebo for 12 weeks, initiated at 1 μg/kg/week, escalated to 5 μg/kg/week, and then tapered. Median patients' age was 8.5 years, and the median baseline platelet count (PC) was 10.5×10 9/L. The median weekly dose of romiplostim was 2 μg/kg. Fifty percent of patients in both romiplostim and placebo arms had at least one adverse event (AE); none was serious. Ten patients on romiplostim (83.3%) maintained the efficacy endpoint (PC>50,000). Romiplostim was well-tolerated and efficient in treating the children with chronic refractory ITP with no unexpected AEs. © Springer-Verlag 2011.
Authors & Co-Authors
ElAlfy, Mohsen Saleh
Egypt, Cairo
Ain Shams University
Abdelmaksoud, Abeer Ahmed
Egypt, Cairo
Ain Shams University
Eltonbary, Khadiga Yehia Elsayed Mousa
Egypt, Cairo
Ain Shams University
Statistics
Citations: 70
Authors: 3
Affiliations: 1
Identifiers
Doi:
10.1007/s00277-011-1172-9
ISSN:
09395555
e-ISSN:
14320584
Research Areas
Maternal And Child Health