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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Quality of life in systemic lupus erythematosus: Description in a cohort of French patients and association with blood hydroxychloroquine levels
Lupus, Volume 25, No. 7, Year 2016
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Description
Objectives Benefits of hydroxychloroquine (HCQ) use on physician reported outcomes are well documented in systemic lupus erythematosus (SLE). We assess for the first time the association and predictive value of blood HCQ levels towards health-related quality of life (HRQOL) in SLE. Methods Data from the PLUS study (a randomized, double-blind, placebo-controlled, multicentre study) were utilized. Blood HCQ levels were quantified by high-performance liquid chromatography along with HRQOL assessments (Medical Outcomes Study-SF-36) at baseline (V1) and month 7 (V2). Results 166 SLE patients' data were analysed. Mean (SD) age and disease duration were 44.4 (10.7) and 9.3 (6.8) years. Eighty-seven per cent were women. Mean (SD, median, IQR) HCQ concentrations in the blood at V1 were 660 (314, 615, 424) ng/ml and increased to 1020 (632, 906, 781) ng/ml at V2 (mean difference 366 units, 95% confidence interval -472 to -260, p < 0.001). No significant correlations between HCQ concentrations with HRQOL domains at V1 or V2 were noted. There were no differences in HRQOL stratified by HCQ concentrations. HCQ concentrations at V1 or changes in HCQ concentration (V2-V1) were not predictive of HRQOL at V2 or changes in HRQOL (V2-V1). Conclusions No association of HCQ concentrations with current or longitudinal HRQOL were found in SLE. © 2016 The Author(s).
Authors & Co-Authors
Jolly, Meenakshi
United States, Chicago
Rush University Medical Center
Galicier, Lionel
France, Paris
Hôpital Saint-louis
Aumaìtre, Olivier
France, Clermont-ferrand
Centre Hospitalier Universitaire de Clermont-ferrand
Françès, Carnille
France, Paris
Hôpital Tenon
Le-Guern, Véronique
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Smaïl, Amar
France, Amiens
Chu Amiens Picardie
Limal, Nicolas
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Pérard, Laurent
France, Lyon
Chu de Lyon
Desmurs-Clavel, Hélène
France, Lyon
Chu de Lyon
Asli, Bouchra
France, Paris
Hôpital Saint-louis
Kahn, Jean Emmanuel
France, Suresnes
Hopital Foch
Pourrat, Jacques P.
France, Toulouse
Université Toulouse Iii - Paul Sabatier
Sailler, Laurent J.
France, Toulouse
Université Toulouse Iii - Paul Sabatier
Ackermann, Félix
France, Suresnes
Hopital Foch
Papo, Thomas
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Sacré, Karim
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Fain, Olivier
France, Paris
Sorbonne Université
Stirnemann, Jérôme
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Cacoub, Patrice P.
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Jallouli, Moez
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Leroux, Gaëlle D.
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Cohen-Bittan, Judith
France, Paris
Hôpital Tenon
Hulot, Jean Sebastien
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Amoura, Zahir
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Piette, Jean Charles
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
CostéDoat-Chalumeau, Nathalie
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Statistics
Citations: 20
Authors: 26
Affiliations: 13
Identifiers
Doi:
10.1177/0961203315627200
ISSN:
09612033
Research Areas
Disability
Study Design
Cohort Study
Participants Gender
Female