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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
PFMDR1 and in vivo resistance to artesunate-mefloquine in falciparum malaria on the Cambodian-Thai border
American Journal of Tropical Medicine and Hygiene, Volume 76, No. 4, Year 2007
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Description
Artemisinin combination therapies (ACTs) have recently been adopted as first-line therapy for Plasmodium falciparum infections in most malaria-endemic countries. In this study, we estimated the association between artesunate-mefloquine therapy failure and genetic changes in the putative transporter, pfmdr1. Blood samples were acquired from 80 patients enrolled in an 2004 in vivo efficacy study in Pailin, Cambodia, and genotyped for pfmdr1 copy number and haplotype. Having parasites with three or more copies of pfmdr1 before treatment was strongly associated with recrudescence (hazard ratio [HR] = 8.30; 95% CI: 2.60-26.43). This relationship was maintained when controlling for initial parasite density and hematocrit (HR = 7.91; 95% CI: 2.38-26.29). Artesunate-mefloquine treatment selected for increased pfmdr1 copy number, because isolates from recurrent episodes had higher copy numbers than the paired enrollment samples (Wilcoxon rank test, P = 0.040). pfmdr1 copy number should be evaluated further as a surveillance tool for artesunate-mefloquine resistance in Cambodia. Copyright © 2007 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Alker, Alisa P.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Lim, Pharath
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Sem, Rithy
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Yi, Poravuth
Cambodia, Phnom Penh
National Center for Parasitology, Entomology and Malaria Control
Tsuyuoka, Reiko
Laos, Vientiane
Lao People's Democratic Republic
Maguire, Jason D.
Unknown Affiliation
Fandeur, Thierry
France, Paris
Cnrs Centre National de la Recherche Scientifique
Ariey, Frédéric
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Wongsrichanalai, Chansuda
Cambodia, Phnom Penh
National Institute of Public Health
Meshnick, Steven Richard
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Statistics
Citations: 210
Authors: 10
Affiliations: 7
Identifiers
Doi:
10.4269/ajtmh.2007.76.641
ISSN:
00029637
Research Areas
Environmental
Genetics And Genomics
Health System And Policy
Infectious Diseases