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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
In vitro activity of Cameroonian and Ghanaian medicinal plants on parasitic (Onchocerca ochengi) and free-living (Caenorhabditis elegans) nematodes
Journal of Helminthology, Volume 85, No. 3, Year 2011
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Description
Ethanolic and aqueous extracts of selected medicinal plants from Cameroon and Ghana were assessed for their in vitro anthelmintic activity by using the bovine filarial parasite Onchocerca ochengi and the free living nematode Caenorhabditis elegans, a model organism for research on nematode parasites. Worms were incubated in the presence of different concentrations of extracts and inhibitory effects were monitored at different time points. Among the extracts used in this study, ethanolic extracts of Anogeissus leiocarpus, Khaya senegalensis, Euphorbia hirta and aqueous extracts from Annona senegalensis and Parquetina nigrescens affected the growth and survival of C. elegans and O. ochengi significantly. The mortality was concentration dependent with an LC50 ranging between 0.38 and 4.00 mg/ml for C. elegans (after 72 h) and between 0.08 and 0.55 mg/ml for O. ochengi after a 24 h incubation time. Preliminary phytochemical screenings on these extracts revealed the presence of flavonoids, alkaloids, saponins, carbohydrates and tannins in the extracts. Accordingly, application of A. leiocarpus, K. senegalensis, E. hirta and A. senegalensis extracts could provide alternatives in the control of helminthic infections. © 2010 Cambridge University Press.
Authors & Co-Authors
Ndjonka, Dieudonné
Cameroon, Ngaoundere
University of Ngaoundere
Germany, Munster
Institute for Zoophysiology
Agyare, C.
Germany, Munster
University of Münster
Lüersen, Kai
Germany, Munster
Institute for Zoophysiology
Boursou, Djafsia
Cameroon, Ngaoundere
University of Ngaoundere
Achukwi, D.
Cameroon, Yaounde
Ministry of Scientific Research and Innovation-cameroon
Nukenine, Elias Nchiwan
Cameroon, Ngaoundere
University of Ngaoundere
Hensel, Andreas
Germany, Munster
University of Münster
Liebau, Eva
Germany, Munster
Institute for Zoophysiology
Statistics
Citations: 66
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1017/S0022149X10000635
ISSN:
0022149X
e-ISSN:
14752697
Study Locations
Cameroon
Ghana