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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Gynecological organ involvement at robot-assisted radical cystectomy in females: Is anterior exenteration necessary?
Canadian Urological Association Journal, Volume 12, No. 9, Year 2018
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Description
Introduction: We aimed to investigate patient and disease variables associated with gynecological organ invasion in females with bladder cancer at the time of robot-assisted radical cystectomy (RARC). Methods: We conducted a retrospective review of female patients who underwent robot-assisted anterior pelvic exenteration (RAAE) between 2005 and 2016. Patients were divided into two groups: those with gynecological organ involvement at RAAE and those without. Data were reviewed for perioperative and pathological outcomes. Kaplan-Meier method was used to depict survival outcomes. Multivariable stepwise regression analysis was performed to identify predictors of gynecological organ involvement. Results: A total of 118 female patients were identified; 17 (14%) showed evidence of gynecological organ invasion at RAAE. Patients with gynecological organ invasion had more lymphovascular invasion at transurethral resection of bladder tumour (TURBT) (82% vs. 46%; p=0.006), trigonal tumours at TURBT (59% vs. 18%; p=0.001), multifocal disease (65% vs. 33%; p=0.01), pN+ (71% vs. 22%; p<0.001), positive surgical margins (24% vs. 4%; p=0.02), and they less commonly demonstrated pure urothelial carcinoma at TURBT (18% vs. 66%; p<0.001). On multivariate analysis, significant predictors of gynecological organ invasion were pN-positive disease (odds ratio [OR] 6.48; 95% confidence interval [CI] 1.64–25.51; p=0.008), trigonal tumour location (OR 5.72; 95% CI 1.39–23.61; p=0.02), and presence of variant histology (OR 18.52; 95% CI 3.32–103.4; p=0.001). Conclusions: Patients with trigonal tumours, variant histology, and nodal involvement are more likely to have gynecological organ invasion at RAAE. This information may help improve counselling of patients and better identify candidates for gynecological organ-sparing cystectomy. © 2018 Canadian Urological Association.
Authors & Co-Authors
Whittum, Michelle
United States, Buffalo
Roswell Park Cancer Institute
Hussein, Ahmed Aly
United States, Buffalo
Roswell Park Cancer Institute
Ahmed, Youssef E.
United States, Buffalo
Roswell Park Cancer Institute
Khan, Hijab
United States, Buffalo
Roswell Park Cancer Institute
Krasowski, Collin
United States, Buffalo
Roswell Park Cancer Institute
May, Paul R.
United States, Buffalo
Roswell Park Cancer Institute
Terakawa, Tomoaki
Japan, Kobe
Kobe University
Li, Qiang J.
United States, Buffalo
Roswell Park Cancer Institute
Guru, Khurshid Ahad
United States, Buffalo
Roswell Park Cancer Institute
Statistics
Citations: 6
Authors: 9
Affiliations: 2
Identifiers
Doi:
10.5489/cuaj.5086
ISSN:
19116470
Research Areas
Cancer
Health System And Policy
Study Design
Cohort Study
Case-Control Study
Study Approach
Quantitative
Participants Gender
Female